Pavan Cheruvu, Bitterroot Bio CEO

Scoop: As Sio clos­es, for­mer CEO from ‘vant ex­it finds him­self at helm of Irv Weiss­man stealth biotech

Stan­ford stem cell lu­mi­nary Irv Weiss­man is build­ing a new biotech around the ‘don’t eat me’ sig­nal CD47 — but in­stead of can­cer, the new biotech is de­vel­op­ing an­ti-CD47 ther­a­pies for heart dis­ease.

Bit­ter­root Bio, named af­ter the Bit­ter­root riv­er in Weiss­man’s home state of Mon­tana, “like­ly will un­veil our in­ten­tions ear­ly in 2023,” co-founder Nicholas Leep­er told End­points News in an email, though he de­clined to say more. Bit­ter­root is go­ing af­ter “ath­er­o­scle­ro­sis from the an­ti-CD47 an­gle,” ac­cord­ing to Weiss­man’s dis­clo­sures in a Na­ture Can­cer pa­per pub­lished in No­vem­ber.

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