Shehnaaz Suli­man dives back in­to Alzheimer's at Alec­tor; Pyx­is re­cruits Spring­Works founder Lara Sul­li­van as CEO

Shehnaaz Suli­man

Amid Shehnaaz Suli­man’s lengthy re­sume it could be easy to miss her stint lead­ing ear­ly-stage Alzheimer’s R&D at Genen­tech, where she over­saw a pro­gram for the ill-fat­ed crenezum­ab and ini­ti­at­ed one of the first pre­ven­tion stud­ies around the dev­as­tat­ing neu­rode­gen­er­a­tive dis­ease. But it is this ex­pe­ri­ence that she — af­ter think­ing long and hard about her next ca­reer move over the past months — will be lean­ing heav­i­ly on as the first pres­i­dent and COO of Alec­tor.

Re­turn­ing to the dis­ease area af­ter spend­ing some years ad­vis­ing and work­ing for sev­er­al com­pa­nies on oth­ers, most re­cent­ly as SVP of cor­po­rate de­vel­op­ment and strat­e­gy at Ther­a­vance, Suli­man sees rea­son to be com­pelled by Alec­tor’s pi­o­neer­ing work in im­muno-neu­rol­o­gy, which is fast ap­proach­ing a piv­otal test loom­ing next year.

“The field has evolved in terms of the so­phis­ti­ca­tion with which we are now able to both iden­ti­fy as well as cor­re­late bio­mark­ers with clin­i­cal out­comes,” she told End­points News.

That in­cludes the work that some of her old col­leagues from Genen­tech are now do­ing at De­nali, just down the road on Oys­ter Point Boule­vard in South San Fran­cis­co. At Alec­tor, their big idea is that ge­net­ic mu­ta­tions and the ag­ing process ac­cel­er­ate senes­cence or de­te­ri­o­ra­tion of the brain im­mune cells. Restor­ing a healthy im­mune sys­tem can ad­dress those is­sues — and with her ex­pe­ri­ence lead­ing clin­i­cal tri­als in mild-to-mod­er­ate Alzheimer’s “I al­most in­tu­itive­ly un­der­stood how this ap­proach could be a game-chang­er.”

In her new role Shehnaaz has broad re­spon­si­bil­i­ty over day-to-day op­er­a­tions in every­thing rang­ing from pre­clin­i­cal de­vel­op­ment to po­ten­tial com­mer­cial­iza­tion strat­e­gy. A key at­trac­tion for the job is to part­ner with Arnon Rosen­thal, founder and CEO, in fig­ur­ing out how to scale the or­ga­ni­za­tion while pre­serv­ing the agili­ty through which the biotech has cre­at­ed 14 can­di­dates and ush­ered four of them in­to the clin­ic with­in five years.

“Arnon is a tow­er­ing leader in the field of neu­rode­gen­er­a­tion and he has built an in­cred­i­ble team,” she said.

She now plans to help grow that team from 117 to be­tween 120 and 140 by the end of the year. And they have got­ten more ex­perts on board for the scale-up: Alec­tor an­nounced this morn­ing that Genen­tech vet Richard Scheller and Stan­ford pro­fes­sor Thomas Süd­hof, renowned neu­ro­sci­en­tists, will co-chair their strate­gic port­fo­lio ad­vice and re­view com­mit­tee. — by Am­ber Tong


Lara Sul­li­van

Lara Sul­li­van was deep in­to seed stage on­col­o­gy op­por­tu­ni­ties, just wrap­ping up a round for a stealth pre­clin­i­cal play­er when she came across the team at Pyx­is On­col­o­gy this sum­mer.

“I im­me­di­ate­ly rec­og­nized the trans­for­ma­tive po­ten­tial of Pyx­is’s nov­el bi­o­log­i­cal ap­proach­es built on the tech­nol­o­gy out of Tom Gajew­s­ki’s lab at Uni­ver­si­ty of Chica­go,” she told End­points News. “The en­thu­si­asm in the sci­en­tif­ic com­mu­ni­ty for Tom’s work com­bined with the horse­pow­er that was al­ready in place through the Se­ries A syn­di­cate of Long­wood, Leaps by Bay­er, Agent Cap­i­tal and Ipsen made it a no-brain­er to jump on board.”

As the new CEO of the com­pa­ny, suc­ceed­ing Long­wood part­ner David Stein­berg, she will keep the team laser-fo­cused on the ear­ly pipeline while bring­ing in the right part­ners for the plat­form, which iden­ti­fies new tar­gets for can­cer im­munother­a­py from the tu­mor mi­croen­vi­ron­ment. CSO Ronald Herb­st, who joined in Oc­to­ber, has helped “set our sci­en­tif­ic strate­gies and rapid­ly at­tract tal­ent,” Sul­li­van said, and their biggest chal­lenge right now re­mains the tech­ni­cal one of pick­ing the right drugs for the right pa­tient pop­u­la­tions.

It has been a year since Sul­li­van left Spring­Works, the biotech she helped spin out of Pfiz­er with mid- to late-stage can­di­dates that didn’t make the cut for in­ter­nal de­vel­op­ment.

“I’ve al­ways felt strong­ly that great sci­ence de­serves the op­por­tu­ni­ty to de­clare it­self, and that at­tri­tion of great sci­ence (whether at dis­cov­ery or clin­i­cal stage) dri­ven by in­suf­fi­cient bud­get or in­ef­fi­cient op­er­a­tions is in­ex­cus­able,” she said.

With $22 mil­lion in Se­ries A fund­ing from deep pock­et­ed in­vestors and an ex­pe­ri­enced team in place, she is count­ing on Pyx­is to tack­le the chal­lenge head on. — by Am­ber Tong


→ More changes at com­ing at Bris­tol-My­ers Squibb. Just a day af­ter con­firm­ing BD chief Paul Bion­di’s de­par­ture, the phar­ma gi­ant said John Elick­er, EVP of cor­po­rate af­fairs and in­vestor re­la­tions, is set to re­tire by the end of March next year. His role will be split in­to two: Kathryn Met­calfe, the chief com­mu­ni­ca­tions of­fi­cer of CVS Health, has been poached to take on the lead in cor­po­rate af­fairs; 13-year vet­er­an Tim Pow­er is be­ing pro­mot­ed to head of in­vestor re­la­tions.

→ Fol­low­ing an FDA OK for its be­ta-tha­lassemia drug Re­blozyl, Ac­celeron Phar­ma has wooed Jay Back­strom, the CMO of its part­ner Cel­gene, to the new­ly cre­at­ed role of head of R&D. Back­strom moves as Cel­gene is be­ing in­te­grat­ed in­to Bris­tol-My­ers Squibb af­ter a $74 bil­lion ac­qui­si­tion. Back­strom’s pre­vi­ous stints span Pharmion, Mar­i­on Mer­rell Dow and Quin­tiles

James Burns

→  San-Diego-based Lo­cana — which launched ear­li­er this year based on ge­net­ic re­search from UC San Diego pro­fes­sor Gene Yeo’s lab — has tapped James Burns to run the com­pa­ny as CEO. Burns suc­ceeds Jef­frey Os­trove, who will con­tin­ue to serve as a board di­rec­tor. Burns joins af­ter a stint as CEO of Case­bia, lead­ing the team in de­vel­op­ing new CRISPR/Cas9 ther­a­peu­tics to treat blood dis­or­ders. Burns al­so brings ex­pe­ri­ence from his time at Sanofi-Gen­zyme to the role.

Leila Al­land

PMV Phar­ma has wel­comed Leila Al­land to the fold as CMO, help­ing push the p53 drug it re­ceived $74 mil­lion back in 2017 to test in hu­mans. Most re­cent­ly, Al­land served in the same role at Af­fimed and has pre­vi­ous­ly held stints at Tarve­da Ther­a­peu­tics, As­traZeneca, Bris­tol-My­ers Squibb, No­var­tis and Scher­ing-Plough

Eli Wal­lace

→ Af­ter drop­ping their bid to re­claim Ei­dos af­ter three of­fer re­jec­tions, Neil Ku­mar-led Bridge­Bio Phar­ma has ap­point­ed Eli Wal­lace as the com­pa­ny’s CSO in res­i­dence for on­col­o­gy. Wal­lace joins the com­pa­ny af­ter a stint as CSO at Pelo­ton Ther­a­peu­tics, the can­cer biotech Mer­ck snapped up for $2.2 bil­lion. Pri­or to Pelo­ton, Wal­lace served in the med­i­c­i­nal chem­istry de­part­ment at Ar­ray Bio­Phar­ma — where he led re­search that pro­duced eight chem­i­cal en­ti­ties for the treat­ment of can­cer, in­clud­ing Mek­tovi.

Take­dapart­nered I/O play­er Shat­tuck Labs has ap­point­ed Casi DeY­oung as CBO. DeY­oung hops aboard af­ter serv­ing as COO at Im­mune­Sen­sor Ther­a­peu­tics. Pri­or to Im­mune­Sen­sor, DeY­oung was CBO of Mir­na Ther­a­peu­tics and had var­i­ous ex­ec roles at Rea­ta Phar­ma­ceu­ti­cals, EMD Phar­ma­ceu­ti­cals and Mer­ck KGaA

Julie Grant

Julie Grant and Bren­dan Dick­in­son have been pro­mot­ed to gen­er­al part­ner at Canaan Part­ners, the Sil­i­con Val­ley-based VC firm known for jump­ing in ear­ly. Grant joined in 2013 as an as­so­ciate, af­ter a stint at Genen­tech, while Dick­in­son start­ed in 2010. Grant is the fourth woman in the com­pa­ny to be­come GP.

Roche has a slew of up­com­ing changes to its board of di­rec­tors and cor­po­rate ex­ec­u­tive com­mit­tee. As an­nounced in Ju­ly 2018, An­dreas Oeri will re­tire from the board along with John Bell — their pro­posed suc­ces­sors are Jörg Duschmalé and CEO of Swiss Life Group Patrick Frost re­spec­tive­ly. In ad­di­tion, Clau­dia Böck­stiegel, the cur­rent head of le­gal of the di­ag­nos­tics di­vi­sion, will suc­ceed gen­er­al coun­sel Got­tlieb Keller, who is step­ping out and in­to re­tire­ment. An­nette Luther, cur­rent­ly gen­er­al man­ag­er of Roche Di­ag­nos­tics In­ter­na­tion­al, will take over for Keller as sec­re­tary to the board of di­rec­tors. 

→ Af­ter se­cur­ing FDA ap­proval for its con­tro­ver­sial lead drug El­zon­ris in use for blas­tic plas­ma­cy­toid den­drit­ic cell neo­plasm (BPD­CN), on­col­o­gy-fo­cused drug de­vel­op­er Stem­line Ther­a­peu­tics has pro­mot­ed Robert Fran­co­mano from the role of SVP, glob­al head of com­mer­cial med­ical af­fairs to that of CCO. Fran­co­mano has held po­si­tions at Bax­al­ta, Pfiz­er, GSK and As­traZeneca — where he played a role with­in the com­pa­ny’s breast can­cer fran­chise.  

→ Af­ter mak­ing its de­but on the Hong Kong Stock Ex­change with a $285 mil­lion IPO in Feb­ru­ary, CStone Phar­ma­ceu­ti­cals has brought on Shirley Zhao as gen­er­al man­ag­er for Greater Chi­na and head of com­mer­cial. Pre­vi­ous­ly, Zhao was the coun­try GM for Bris­tol-My­ers Squibb, where she spear­head­ed the launch for Op­di­vo, the first PD-1 in­hibitor to en­ter the Chi­nese mar­ket. Be­fore that, Zhao had the same job at Gen­zyme and Al­ler­gan

Fresh off a $114 mil­lion round led by Sam­sara and with big plans for its CAR-NK plat­form, Nkar­ta Ther­a­peu­tics has re­cruit­ed On­coMed vet Yvonne Li as SVP, fi­nance and for­mer On­cBio­Mune Phar­ma­ceu­ti­cals CMO Bri­an Bar­nett as SVP, clin­i­cal de­vel­op­ment.

Last year Sue Dil­lon and Karyn O’Neil left J&J to launch fledg­ling Aro Bio­ther­a­peu­tics, and now the com­pa­ny has wel­comed Scott Green­berg as VP, busi­ness de­vel­op­ment and al­liance man­age­ment. Green­berg joins Aro af­ter a stint as VP, head of op­er­a­tions at Roivant Sci­ences. Pri­or to that, Green­berg spent more than a decade at Cel­gene — now swal­lowed by Bris­tol-My­ers in a $74 bil­lion deal — and Gold­man Sachs.

Sean Khozin

→ Ex-FDA of­fi­cial Sean Khozin has made the leap to join Janssen R&D as their glob­al head of da­ta strat­e­gy. Khozin was the for­mer as­so­ciate di­rec­tor for the FDA On­col­o­gy Cen­ter of Ex­cel­lence and found­ing di­rec­tor of the agency’s In­for­ma­tion Ex­change and Da­ta Trans­for­ma­tion (IN­FORMED). Khozin al­so found­ed SKMD, where he was CMO, and Hel­loHealth

Parex­el — which re­cent­ly part­nered up with Vivek Ra­maswamy’s Roivant-spawned Data­vant to em­brace re­al world ev­i­dence — has snatched up some reg­u­la­to­ry pros from the US and UK to join its team. All four will serve as tech­ni­cal vice pres­i­dents. The ad­di­tions in­clude: Mark Birse, for­mer MHRA deputy di­rec­tor of in­spec­tion, en­force­ment and stan­dards di­vi­sion; Philip Crook­er, drug de­vel­op­ment at­tor­ney; Lynne En­sor, who served as FDA act­ing deputy di­rec­tor of the of­fice of process and fa­cil­i­ties; and Yuex­ia Li, most re­cent­ly the FDA deputy di­rec­tor of the of­fice of pro­gram and reg­u­la­to­ry op­er­a­tions.

→ San Fran­cis­co start­up Verge Ge­nomics has ap­point­ed Thomas Large, the cur­rent CEO and co-founder of Blue Oak Phar­ma­ceu­ti­cals, and James Sum­mers, for­mer VP of neu­ro­science re­search at Ab­b­Vie, to its sci­en­tif­ic ad­vi­so­ry board. 

IDC: Life Sci­ences Firms Must Em­brace Dig­i­tal Trans­for­ma­tion Now

Pre-pandemic, the life sciences industry had settled into a pattern. The average drug took 12 years and $2.9 billion to bring to market, and it was an acceptable mode of operations, according to Nimita Limaye, Research Vice President for Life Sciences R&D Strategy and Technology at IDC.

COVID-19 changed that, and served as a proof-of-concept for how technology can truly help life sciences companies succeed and grow, Limaye said. She recently spoke about industry trends at Egnyte’s Life Sciences Summit 2022. You should watch the entire session, free and on-demand, but here’s a brief recap of why she’s urging life sciences companies to embrace digital transformation.

Paul Hudson, Sanofi CEO (Eric Piermont/AFP via Getty Images)

Up­dat­ed: Hit by an­oth­er PhI­II flop, Sanofi culls breast can­cer drug — sound­ing alarm for the class

Sanofi is officially giving up on its oral SERD.

The French drugmaker put out word Wednesday morning that it will discontinue the global development program of amcenestrant, the selective estrogen receptor degrader once billed as a top late-stage prospect. Having already failed a Phase II monotherapy test earlier this year, a combo with the drug also missed the bar in a second trial for breast cancer, triggering the decision to drop the whole program.

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Tom Barnes, Orna Therapeutics CEO

UP­DAT­ED: 'We have failed to fail': Mer­ck gam­bles $250M cash on a next-gen ap­proach to mR­NA — af­ter punt­ing its big al­liance with Mod­er­na

Merck went in deep on its collaboration with Moderna on new mRNA programs, and dropped them all over time, including their RSV partnership. But after writing off what turned out as one of the most successful infectious disease players in the business, Merck is coming in this morning with a new preclinical alliance — this time embracing a biotech that hopes to eventually outdo the famously successful mRNA in a new run at vaccines and therapeutics.

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Bayer's first DTC ad campaign for chronic kidney disease drug Kerendia spells out its benefits

Bay­er aims to sim­pli­fy the com­plex­i­ties of CKD with an ABC-themed ad cam­paign

Do you know the ABCs of CKD in T2D? Bayer’s first ad campaign for Kerendia tackles the complexity of chronic kidney disease with a play on the acronym (CKD) and its connection to type 2 diabetes (T2D).

Kerendia was approved last year as the first and only non-steroidal mineralocorticoid receptor antagonist to treat CKD in people with type 2 diabetes.

In the TV commercial launched this week, A is for awareness, B is for belief and C is for cardiovascular, explained in the ad as awareness of the connection between type 2 and kidney disease, belief that something can be done about it, and cardiovascular events that may be reduced with treatment.

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James Mock, incoming CFO at Moderna

Mod­er­na taps new CFO from PerkinElmer af­ter for­mer one-day CFO oust­ed

When Moderna hired a new CFO last year,  it didn’t expect to see him gone after only one day. Today the biotech named his — likely much more vetted — replacement.

The mRNA company put out word early Wednesday that after the untimely departure of then brand-new CFO Jorge Gomez, it has now found a replacement in James Mock, the soon-to-be former CFO at diagnostics and analytics company PerkinElmer.

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Etleva Kadilli, director of UNICEF’s supply division

GSK lands first-ever UNICEF con­tract for malar­ia vac­cine worth $170M

GSK has landed a new first from UNICEF the first-ever contract for malaria vaccines, worth up to $170 million for 18 million vaccine doses distributed over the next three years.

The vaccine, known as Mosquirix or RTS,S, won WHO’s backing last October after a controversial start, but UNICEF said these doses will potentially save thousands of lives every year.

“We hope this is just the beginning,” Etleva Kadilli, director of UNICEF’s supply division, said. “Continued innovation is needed to develop new and next-generation vaccines to increase available supply, and enable a healthier vaccine market. This is a giant step forward in our collective efforts to save children’s lives and reduce the burden of malaria as part of wider malaria prevention and control programmes.”

Joe Jonas (Photo by Anthony Behar/Sipa USA)(Sipa via AP Images)

So­lo Jonas broth­er car­ries Merz's new tune in Botox ri­val cam­paign

As the lyrics of his band’s 2019 pop-rock single suggest, Joe Jonas is only human — and that means even he gets frown lines. The 33-year-old singer-songwriter is Merz’s newest celebrity brand partner for its Botox rival Xeomin, as medical aesthetics brands target a younger audience.

Merz kicked off its “Beauty on Your Terms” campaign on Tuesday, featuring the Jonas brother in a video ad for its double-filtered anti-wrinkle injection Xeomin.

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Marisol Peron, Genmab SVP of communications and corporate affairs

Gen­mab launch­es cor­po­rate cam­paign am­pli­fy­ing its ‘knock your socks off’ an­ti­bod­ies

Genmab often talks about its “knock-your-socks-off” antibodies — and now the term is getting its own logo and corporate campaign.

The teal and purple logo for the acronym KYSO — Genmab pronounces it “ky-so” — debuts on Wednesday and comes on the heels of Genmab’s newly announced 2030 vision. That aspiration aims to expand Genmab’s drug development beyond oncology to include other serious diseases, while also doubling down on its own drug development.

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Joel Dudley, new partner at Innovation Endeavors (Bosch Health Campus)

For­mer Google CEO’s VC is mak­ing a big­ger push in­to the biotech world, hir­ing promi­nent Ther­a­nos skep­tic

Venture capital firm Innovation Endeavors has mainly had its focus on investments across the tech space, but it has been slowly turning its attention to the biotech world. Now, a new partner is coming into the fold showing that its interest in biotech is likely to grow further.

The Silicon Valley-based company, which is headed up by former Google CEO Eric Schmidt, has brought on Joel Dudley as a partner. According to Dudley’s LinkedIn page, he is joining Innovation Endeavors after serving as the chief science officer of biotech startup Tempus Labs since 2020.

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