Spurned by Ab­b­Vie, Abl­ynx wins an­oth­er Big Phar­ma part­ner of­fer­ing a block­buster prize for suc­cess

Sanofi CEO Olivi­er Brandi­court (left), flanked by CFO Jerome Con­t­a­mine, speaks dur­ing a Feb­ru­ary 2017 com­pa­ny pre­sen­ta­tion get­ty


Nine months af­ter Ab­b­Vie dealt Abl­ynx a blow by walk­ing away from a messy rheuma­toid arthri­tis drug it was part­nered on, the Bel­gian biotech has come back and added an­oth­er Big Phar­ma com­pa­ny to its list of part­ners for its Nanobody plat­form tech. And this one is dan­gling a trea­sure trove of mile­stone pay­ments if its re­searchers can turn in a block­buster per­for­mance.

Sanofi is jump­ing on board to­day, pay­ing a mod­est $28 mil­lion to get the part­ner­ship start­ed and of­fer­ing up to $2.8 bil­lion in mile­stones in the deal. Their fo­cus is on im­mune-me­di­at­ed in­flam­ma­to­ry dis­eases, which cov­ers quite a bit of bi­o­log­ic ter­ri­to­ry. But there wasn’t a lot of de­tail in­to what they planned to go af­ter to­geth­er.

Last Oc­to­ber Ab­b­Vie wrote off its pact with Abl­ynx along with its $175 mil­lion up­front af­ter its IL-6R drug vo­bar­il­izum­ab per­formed poor­ly in ad­vanced clin­i­cal tri­als for rheuma­toid arthri­tis. Not on­ly did the treat­ment flop on the ACR20 goal, it al­so failed on a score of im­proved phys­i­cal func­tion when com­bined with methotrex­ate against methotrex­ate alone. And ear­li­er the Abl­ynx pro­gram had proved at best a matchup to Roche’s Actem­ra, ap­proved sev­en years ago. And that hap­pened while a slate of ma­jor play­ers were ad­vanc­ing their own drugs through Phase III. Ab­b­Vie has an in-house pro­gram it’s al­so con­sid­er­ably pumped about.

Abl­ynx is al­ready aligned with both Mer­cks, No­var­tis and No­vo Nordisk, among oth­ers. Sanofi CEO Olivi­er Brandi­court is un­der con­sid­er­able pres­sure to build up its pipeline, though its part­ner­ship with Re­gen­eron has paid off with a string of ma­jor drug ap­provals, in­clud­ing re­cent OKs for their IL-6 rheuma­toid arthri­tis heavy­weight sar­ilum­ab and Dupix­ent.

Frank Nes­tle, Sanofi’s CSO for North Amer­i­ca, had this to say about the new pact:

This col­lab­o­ra­tion is the lat­est ex­am­ple of Sanofi’s strate­gic com­mit­ment to ex­pand our drug dis­cov­ery pipeline in im­munol­o­gy at a time when we are launch­ing new treat­ments for atopic der­mati­tis and rheuma­toid arthri­tis. We are par­tic­u­lar­ly ex­cit­ed by the Abl­ynx tech­nol­o­gy as a lead­ing bi­o­log­ics plat­form, en­abling the de­vel­op­ment of trans­for­ma­tive mul­ti-tar­get­ing treat­ment ap­proach­es. Through ex­ter­nal part­ner­ships like these, com­bined with our in­ter­nal R&D ex­per­tise, we aim to trans­form the treat­ment land­scape for pa­tients liv­ing with au­toim­mune and in­flam­ma­to­ry con­di­tions.

Jim Mellon [via YouTube]

Health­i­er, longer lifes­pans will be a re­al­i­ty soon­er than you think, Ju­ve­nes­cence promis­es as it clos­es $100M round

Earlier this year, an executive from Juvenescence-backed AgeX predicted the field of longevity will eventually “dwarf the dotcom boom.” Greg Bailey, the UK-based anti-aging biotech’s CEO, certainly hopes so.

On Monday, Juvenescence completed its $100 million series B round of financing. The company is backed by British billionaire Jim Mellon — who wrote his 400-page guide to investing in the field of longevity shortly after launching the company in 2017.  Bailey, who served as a board director for seven years at Medivation before Pfizer swallowed the biotech for $14 billion, is joined by Declan Doogan, an industry veteran with stints at Pfizer and Amarin.

John Hood [file photo]

UP­DATE: Cel­gene and the sci­en­tist who cham­pi­oned fe­dra­tinib's rise from Sanofi's R&D grave­yard win FDA OK

Six years after Sanofi gave it up for dead, the FDA has approved the myelofibrosis drug fedratinib, now owned by Celgene.

The drug will be sold as Inrebic, and will soon land in the portfolio at Bristol-Myers Squibb, which is finalizing a deal to acquire Celgene.

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UP­DAT­ED: AveX­is sci­en­tif­ic founder was axed — and No­var­tis names a new CSO in wake of an ethics scan­dal

Now at the center of a storm of controversy over its decision to keep its knowledge of manipulated data hidden from regulators during an FDA review, Novartis CEO Vas Narasimhan has found a longtime veteran in the ranks to head the scientific work underway at AveXis, where the incident occurred. And the scientific founder has hit the exit.

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Ab­b­Vie gets its FDA OK for JAK in­hibitor upadac­i­tinib, but don’t look for this one to hit ex­ecs’ lofty ex­pec­ta­tions

Another big drug approval came through on Friday afternoon as the FDA OK’d AbbVie’s upadacitinib — an oral JAK1 inhibitor that is hitting the rheumatoid arthritis market with a black box warning of serious malignancies, infections and thrombosis reflecting fears associated with the class.

It will be sold as Rinvoq — at a wholesale price of $59,000 a year — and will likely soon face competition from a drug that AbbVie once controlled, and spurned. Reuters reports that a 4-week supply of Humira, by comparison, is $5,174, adding up to about $67,000 a year.

The top 10 fran­chise drugs in bio­phar­ma his­to­ry will earn a to­tal of $1.4T (tril­lion) by 2024 — what does that tell us?

Just in case you were looking for more evidence of just how important Amgen’s patent win on Enbrel is for the company and its investors, EvaluatePharma has come up with a forward-looking consensus estimate on what the list of top 10 drugs will look like in 2024.

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UP­DAT­ED: Sci­en­tist-CEO ac­cused of im­prop­er­ly us­ing con­fi­den­tial in­fo from uni­corn Alec­tor

The executive team at Alector $ALEC has a bone to pick with scientific co-founder Asa Abeliovich. Their latest quarterly rundown has this brief note buried inside:

On June 18, 2019, we initiated a confidential arbitration proceeding against Dr. Asa Abeliovich, our former consulting co-founder, related to alleged breaches of his consulting agreement and the improper use of our confidential information that he learned during the course of rendering services to us as our consulting Chief Scientific Officer/Chief Innovation Officer. We are in the early stage of this arbitration proceeding and are unable to assess or provide any assurances regarding its possible outcome.

There’s no explicit word in the filing on what kind of confidential info was involved, but the proceeding got started 2 days ahead of Abeliovich’s IPO.

Abeliovich, formerly a tenured associate professor at Columbia, is a top scientist in the field of neurodegeneration, which is where Alector is targeted. More recently, he’s also helped start up Prevail Therapeutics as the CEO, which raised $125 million in an IPO. And there he’s planning on working on new gene therapies that target genetically defined subpopulations of Parkinson’s disease. Followup programs target Gaucher disease, frontotemporal dementia and synucleinopathies.

But this time Abeliovich is the CEO rather than a founding scientist. And some of their pipeline overlaps with Alector’s.

Abeliovich and Prevail, though, aren’t taking this one lying down.

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Chi­na has be­come a CEO-lev­el pri­or­i­ty for multi­na­tion­al phar­ma­ceu­ti­cal com­pa­nies: the trend and the im­pli­ca­tions

After a “hot” period of rapid growth between 2009 and 2012, and a relatively “cooler” period of slower growth from 2013 to 2015, China has once again become a top-of-mind priority for the CEOs of most large, multinational pharmaceutical companies.

At the International Pharma Forum, hosted in March in Beijing by the R&D Based Pharmaceutical Association Committee (RDPAC) and the Pharmaceutical Research and Manufacturers of America (PhRMA), no fewer than seven CEOs of major multinational pharmaceutical firms participated, including GSK, Eli Lilly, LEO Pharma, Merck KGaA, Pfizer, Sanofi and UCB. A few days earlier, the CEOs of several other large multinationals attended the China Development Forum, an annual business forum hosted by the research arm of China’s State Council. It’s hard to imagine any other country, except the US, having such drawing power at CEO level.

As dis­as­ter struck, Ab­b­Vie’s Rick Gon­za­lez swooped in on Al­ler­gan with an of­fer Brent Saun­ders couldn’t say no to

Early March was a no good, awful, terrible time for Allergan CEO Brent Saunders. His big lead drug had imploded in a Phase III disaster and activists were after his hide — or at least his chairman’s title — as the stock price continued a steady droop that had eviscerated share value for investors.

But it was a perfect time for AbbVie CEO Rick Gonzalez to pick up the phone and ask Saunders if he’d like to consider a “strategic” deal.

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CEO Pascal Soriot via Getty Images

As­traZeneca's jug­ger­naut PARP play­er Lyn­parza scoops up an­oth­er dom­i­nant win in PhI­II as the FDA adds a 'break­through' for Calquence

AstraZeneca’s oncology R&D group under José Baselga keeps churning out hits.

Wednesday morning the pharma giant and their partners at Merck parted the curtains on a successful readout for their Phase III PAOLA-1 study, demonstrating statistically significant improvement in progression-free survival for women with ovarian cancer in a first-line maintenance setting who added their PARP Lynparza to Avastin. This is their second late-stage success in ovarian cancer, which will help stave off rivals like GSK.

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