Stuart Lipton offers a new possible reason why all the Alzheimer's drugs have failed
There are a few commonly trotted out reasons for why virtually every Alzheimer’s drug of the last two decades has failed: Maybe the trials didn’t start early enough in the course of disease, or maybe they didn’t go after the right group of patients?
As companies have started earlier and on more select groups of patients, another conclusion has grown increasingly popular: Maybe they’ve all gone after the wrong target. Maybe clearing the misfolded plaques that buildup in patients’ brains, as these therapies have, just wipes away one symptom of the disease but not the root cause.
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