Take­da posts 'for-sale' sign on com­pa­ny's an­ces­tral home in Os­a­ka in ef­fort to fund Shire buy­out

Faced with pres­sures of debt that will ac­com­pa­ny its mam­moth Shire ac­qui­si­tion, Take­da is sell­ing its Os­a­ka head­quar­ters in a move to add about $542 mil­lion (60 bil­lion yen) to the bank.

Christophe We­ber

The news, first re­port­ed by Nikkei, comes just as the Japan­ese drug­mak­er cut the rib­bon on its shin­ing new Tokyo digs, and sym­bol­izes — at least to some — an­oth­er de­par­ture from its roots. Since its found­ing in 1781, Take­da has been based in Os­a­ka.

Di­ves­ture of prop­er­ties, how­ev­er, should come as no sur­prise to com­pa­ny in­sid­ers, as they watched CEO Christophe We­ber sell­ing off three of­fice build­ings in Tokyo, in­clud­ing its for­mer re­gion­al head­quar­ters, in the past year or so.

Take­da is plan­ning to ini­ti­ate a bid­ding process by Oc­to­ber, Nikkei re­ports, with hopes to find buy­ers by the end of the year. It, how­ev­er, will con­tin­ue op­er­at­ing out of these build­ings by leas­ing. It’s all part of the plan to shed as­sets con­sid­ered non-core to the drug­mak­ing busi­ness.

At the open­ing of the 24-sto­ry Tokyo build­ing that will now house Take­da’s glob­al op­er­a­tions, We­ber tout­ed the “mod­ern de­sign lead­ing to a Japan­ese root.” Here’s how Bloomberg de­scribed it: “A se­ries of eight Japan­ese char­ac­ters make up the pat­terns print­ed on the cream car­pet, jut­ting out of the wood­en walls and cut in­to met­al fix­tures. Em­ploy­ees work in an open of­fice lay­out on every floor with glass meet­ing rooms set in a cor­ner.”

Not every­one is pleased with We­ber’s blend of Japan­ese her­itage and glob­al am­bi­tions, though — or even his way of do­ing busi­ness.

Last week, a small coali­tion of old guards failed to push through a pro­pos­al that ad­vance share­hold­er ap­proval be re­quired for an ac­qui­si­tion, which threat­ened to block the $62 bil­lion Shire deal. It didn’t pass — not even close — but be­hind them a slate of an­a­lysts is lin­ing up to poke holes in We­ber’s vi­sion for a Take­da-Shire union.

We­ber has made his res­o­lu­tion clear, and it will be a few more months be­fore we find out where the de­ci­sive vote falls.

Im­age: Take­da Os­a­ka head­quar­ters. TAKE­DA

Norbert Bischofberger. Kronos

Backed by some of the biggest names in biotech, Nor­bert Bischof­berg­er gets his megaround for plat­form tech out of MIT

A little over a year ago when I reported on Norbert Bischofberger’s jump from the CSO job at giant Gilead to a tiny upstart called Kronos, I noted that with his connections in biotech finance, that $18 million launch round he was starting off with could just as easily have been $100 million or more.

With his first anniversary now behind him, Bischofberger has that mega-round in the bank.

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Francesco De Rubertis

Medicxi is rolling out its biggest fund ever to back Eu­rope's top 'sci­en­tists with strange ideas'

Francesco De Rubertis built Medicxi to be the kind of biotech venture player he would have liked to have known back when he was a full time scientist.

“When I was a scientist 20 years ago I would have loved Medicxi,’ the co-founder tells me. It’s the kind of place run by and for investigators, what the Medicxi partner calls “scientists with strange ideas — a platform for the drug hunter and scientific entrepreneur. That’s what I wanted when I was a scientist.”

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Af­ter a decade, Vi­iV CSO John Pot­tage says it's time to step down — and he's hand­ing the job to long­time col­league Kim Smith

ViiV Healthcare has always been something unique in the global drug industry.

Owned by GlaxoSmithKline and Pfizer — with GSK in the lead as majority owner — it was created 10 years ago in a time of deep turmoil for the field as something independent of the pharma giants, but with access to lots of infrastructural support on demand. While R&D at the mother ship inside GSK was souring, a razor-focused ViiV provided a rare bright spot, challenging Gilead on a lucrative front in delivering new combinations that require fewer therapies with a more easily tolerated regimen.

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Novotech CRO Ex­pands Chi­na Team as Biotech De­mand for Clin­i­cal Tri­als In­creas­es up to 79%

An increase in demand of up to 79% for clinical trials in China has prompted Novotech the Asia-Pacific CRO to rapidly expand the China team, appointing expert local clinical executives to their Shanghai and Hong Kong offices. The company is planning to expand their team by 30% over the next quarter.

Novotech China has seen considerable demand recently which is borne out by research from GlobalData:
A global migration of clinical research is occurring from high-income countries to low and middle-income countries with emerging economies. Over the period 2017 to 2018, for example, the number of clinical trial sites opened by biotech companies in Asia-Pacific increased by 35% compared to 8% in the rest of the world, with growth as high as 79% in China.
Novotech CEO Dr John Moller said China offers the largest population in the world, rapid economic growth, and an increasing willingness by government to invest in research and development.
Novotech’s 23 years of experience working in the region means we are the ideal CRO partner for USA biotechs wanting to tap the research expertise and opportunities that China offers.
There are over 22,000 active investigators in Greater China, with about 5,000 investigators with experience on at least 3 studies (source GlobalData).

On a glob­al romp, Boehringer BD team picks up its third R&D al­liance for Ju­ly — this time fo­cused on IPF with $50M up­front

Boehringer Ingelheim’s BD team is on a global deal spree. The German pharma company just wrapped its third deal in 3 weeks, going back to Korea for its latest pipeline pact — this time focused on idiopathic pulmonary fibrosis.

They’re handing over $50 million to get their hands on BBT-877, an ATX inhibitor from Korea’s Bridge Biotherapeutics that was on display at a science conference in Dallas recently. There’s not a whole lot of data to evaluate the prospects here.

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Servi­er scoots out of an­oth­er col­lab­o­ra­tion with Macro­Gen­ics, writ­ing off their $40M

Servier is walking out on a partnership with MacroGenics $MGNX — for the second time.

After the market closed on Wednesday MacroGenics put out word that Servier is severing a deal — inked close to 7 years ago — to collaborate on the development of flotetuzumab and other Dual-Affinity Re-Targeting (DART) drugs in its pipeline.

MacroGenics CEO Scott Koenig shrugged off the departure of Servier, which paid $20 million to kick off the alliance and $20 million to option flotetuzumab — putting a heavily back-ended $1 billion-plus in additional biobuck money on the table for the anti-CD123/CD3 bispecific and its companion therapies.

Den­mark's Gen­mab hits the jack­pot with $500M+ US IPO as small­er biotechs rake in a com­bined $147M

Danish drugmaker Genmab A/S is off to the races with perhaps one of the biggest biotech public listings in decades, having reaped over $500 million on the Nasdaq, as it positions itself as a bonafide player in antibody-based cancer therapies.

The company, which has long served as J&J’s $JNJ key partner on the blockbuster multiple myeloma therapy Darzalex, has asserted it has been looking to launch its own proprietary product — one it owns at least half of — by 2025.

FDA over­rides ad­comm opin­ions a fifth of the time, study finds — but why?

For drugmakers, FDA advisory panels are often an apprehended barometer of regulators’ final decisions. While the experts’ endorsement or criticism often translate directly to final outcomes, the FDA sometimes stun observers by diverging from recommendations.

A new paper out of Milbank Quarterly put a number on that trend by analyzing 376 voting meetings and subsequent actions from 2008 through 2015, confirming the general impression that regulators tend to agree with the adcomms most of the time — with discordances in only 22% of the cases.

UP­DAT­ED: With loom­ing ‘apoc­a­lypse of drug re­sis­tance,’ Mer­ck’s com­bi­na­tion an­tibi­ot­ic scores FDA ap­proval on two fronts

Merck — one of the last large biopharmaceuticals companies in the beleaguered field of antibiotic drug development — on Wednesday said the FDA had sanctioned the approval of its combination antibacterial for the treatment of complicated urinary tract and intra-abdominal infections.

To curb the rise of drug-resistant bacteria and maintain the efficacy of the therapy, Recarbrio (and other antibacterials) — the drug must be used to treat or prevent infections that are proven or strongly suspected to be caused by susceptible gram-negative bacteria, Merck $MRK said.

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