Takeda R&D team rings the blockbuster bell with key PhIII success in frontline lung cancer
Takeda R&D chief Andy Plump hit the money shot with a head-to-head Phase III study pitting Alunbrig (brigatinib) against Pfizer’s Xalkori in a group of ALK+ non-small cell lung cancer patients.
Researchers say their drug hit the primary endpoint on progression-free survival. Currently not approved for frontline use, the drug was tested in patients who had not yet received an ALK inhibitor.
Approved last April for treatment-resistant cases of ALK+ NSCLC, Takeda has been pursuing evidence that their drug can garner more than a billion dollars a year in sales, a stretch above the $500 million to $800 million mark that analysts have projected. And now they plan to hustle up a supplemental approval to help make that forecast a reality.
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