Takeda strikes a combo I/O discovery pact with Shattuck Labs; Facing FDA rejection, Egalet slashes staff

⇨ Takeda’s Cambridge, MA-based oncology group has struck a discovery deal with Austin-based Shattuck Labs. The deal centers on a combo immuno-oncology approach to drug development, matching a checkpoint strategy with whipping up a T cell attack. Takeda will offer Shattuck unspecified research support in exchange for control of two pre-clinical and four discovery stage cancer programs.

⇨ A few weeks after getting a complete response letter from the FDA for its prior approval supplement of oxy alternative Oxaydo, the Wayne, PA-based Egalet $EGLT has begun cutting staff. In a release the company said it would lay off 40% of its non-sales staff. The CRL proved a nasty setback for the biotech’s stock.

⇨ Alexion Pharmaceuticals and Sema4 inked a strategic partnership to “leverage their shared experience in data science and systems biology to accelerate rare disease diagnosis and therapeutic discovery.”

⇨ The gene therapy biotech Orchard Therapeutics has recruited PTC vet Mark Rothera as its new CEO. Rothera had been the chief commercial officer of the Duchenne muscular disease biotech.

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Research Scientist - Immunology
Recursion Pharmaceuticals Salt Lake City, UT
Director of Operations
Atlas Venture Cambridge, MA

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