The fight against drug-re­sis­tant bac­te­ria march­es for­ward as Adap­tive Phage earns $40M+ Se­ries B

A com­pa­ny work­ing to­ward the field of bac­te­rio­phages, de­vel­op­ing ther­a­pies that use bac­te­ria-killing virus­es, just pulled in a sig­nif­i­cant amount of new cap­i­tal.

Adap­tive Phage Ther­a­peu­tics closed a $40.75 mil­lion Se­ries B, the Gaithers­burg, MD-based biotech an­nounced Tues­day morn­ing. The fi­nanc­ing was led by Deer­field Man­age­ment with par­tic­i­pa­tion from the Mayo Clin­ic, which had been a pre­vi­ous in­vestor.

Bac­te­rio­phages had long been an emp­ty area of re­search in the US, but the field has gar­nered more in­ter­est re­cent­ly as an­tibi­ot­ic-re­sis­tant bac­te­ria con­tin­ue to grow in promi­nence. Some of the ear­li­est sci­en­tists to the­o­rize about their use have thought that find­ing the right phages can lead to bet­ter treat­ments for in­fec­tions and ill­ness­es.

The mol­e­cules are virus­es, and work the same way hu­man-in­fect­ing virus­es do — by en­ter­ing host cells and repli­cat­ing. But in this case the host cells are bac­te­ria. The ul­ti­mate goal of bac­te­rio­phage ther­a­py is to use phages to en­ter bac­te­r­i­al cells and cause them to burst, there­by cur­ing pa­tients.

It’s long proved a dif­fi­cult task, name­ly due to the lack of re­search and fund­ing which is fail­ing to help prove these the­o­ries. Many of the pa­tients who have re­ceived ex­per­i­men­tal bac­te­rio­phage ther­a­pies have al­so been ex­treme­ly sick, with the treat­ments used as last-re­sort op­tions.

Fur­ther­more, there’s the need to iden­ti­fy specif­i­cal­ly which bac­te­r­i­al strain is in­fect­ing pa­tients, and match­ing the right bac­te­rio­phage to the pathogen. Mis­match­ing the two not on­ly won’t help the sick pa­tients, but might end up caus­ing fur­ther harm as well.

For Adap­tive Phage, the funds will go to­ward the ther­a­pies that come out of its pro­pri­etary plat­form. The com­pa­ny is de­vel­op­ing a bank of phages, say­ing it’s col­lect­ed hun­dreds of dif­fer­ent virus­es so far that pro­vide broad cov­er­age against six high-pri­or­i­ty, drug-re­sis­tant bac­te­ria.

Adap­tive Phage’s two lead pro­grams are to treat pros­thet­ic joint in­fec­tion and di­a­bet­ic foot os­teomyelitis, and they al­so plan to use some funds to ad­vance a sus­cep­ti­bil­i­ty test to more quick­ly iden­ti­fy po­ten­tial phage ther­a­pies. The com­pa­ny’s tech­nol­o­gy was orig­i­nal­ly de­vel­oped by the Pen­ta­gon’s biode­fense pro­gram, and Adap­tive Phage ac­quired it in 2017.

Deer­field is no stranger to this area ei­ther, as it bought out Melin­ta in March 2020 af­ter the an­tibi­otics com­pa­ny filed for Chap­ter 11 bank­rupt­cy. The deal turned over con­trol to Deer­field in ex­change for the $140 mil­lion of se­nior debt it holds in the com­pa­ny.

So­cial: Greg Mer­ril, Adap­tive Phage Ther­a­peu­tics CEO (Adap­tive Phage)

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His­toric drug pric­ing re­forms pass; Pfiz­er ac­quires GBT; The long search for non-opi­oid pain drugs; and more

Welcome back to Endpoints Weekly, your review of the week’s top biopharma headlines. Want this in your inbox every Saturday morning? Current Endpoints readers can visit their reader profile to add Endpoints Weekly. New to Endpoints? Sign up here.

The Endpoints Weekly has officially crossed the 60,000 mark on subscribers — thanks to all of your support. As the editorial team grows, we’ve been able to do a lot more, with many of those on display this week. Be sure to check out Lei Lei Wu’s deep dive on pain R&D. If you missed it, you may also rewatch her companion panel here.

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Gold for adults, sil­ver for in­fants: Pfiz­er's Pre­vnar 2.0 head­ed to FDA months af­ter Mer­ck­'s green light

Pfizer was first to the finish line for the next-gen pneumococcal vaccine in adults, but Merck beat its rival with a jab for children in June.

Now, two months after Merck’s 15-valent Vaxneuvance won the FDA stamp of approval for kids, Pfizer is out with some late-stage data on its 20-valent shot for infants.

Known as Prevnar 20 for adults, Pfizer’s 20vPnC will head to the FDA by the end of this year for an approval request in infants, the Big Pharma said Friday morning. Discussions with the FDA will occur first and more late-stage pediatric trials are expected to read out soon, informing the regulatory pathway in other countries and regions.

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No­var­tis re­ports two pa­tient deaths af­ter treat­ment with Zol­gens­ma

Two children with spinal muscular atrophy have died after receiving Novartis’ Zolgensma, a gene therapy designed as a one-time treatment for the rare fatal disease.

The deaths, which resulted from acute liver failure, occurred in Russia and Kazakhstan, Novartis confirmed in a statement to Endpoints News. Having notified health authorities across all the markets where Zolgensma is available, it will update the drug label “to specify that fatal acute liver failure has been reported,” a spokesperson wrote.

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House pass­es his­toric drug pric­ing re­forms, lin­ing up decades-in-the-mak­ing win for Biden and De­moc­rats

The US House of Representatives today voted along party lines (all Dems voted for it), 220-207 to pass new, wide-ranging legislation that will allow Medicare drug price negotiations for the first time ever, and cap seniors’ drug expenses to $2,000 per year and seniors’ insulin costs at $35 per month.

Setting up a major victory for President Joe Biden, representatives returned from their summer recess to pass the Inflation Reduction Act, even as many noted the bill would only modestly reduce inflation.

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Senate Finance Committee Chair Ron Wyden (D-OR) (Francis Chung/E&E News/POLITICO via AP Images)

Sen­ate Fi­nance chair con­tin­ues his in­ves­ti­ga­tion in­to phar­ma tax­es with re­quests for Am­gen

Amgen is the latest pharma company to appear on the radar of Senate Finance Committee Chair Ron Wyden (D-OR), who is investigating the way pharma companies are using subsidiaries in low- or zero-tax countries to lower their tax bills.

Like its peers Merck, AbbVie and Bristol Myers Squibb, Wyden notes how Amgen uses its Puerto Rico operations to consistently pay tax rates that are substantially lower than the U.S. corporate tax rate of 21%, with an effective tax rate of 10.7% in 2020 and 12.1% in 2021.

FDA ap­proves sec­ond in­di­ca­tion for As­traZeneca and Dai­ichi's En­her­tu in less than a week

AstraZeneca and Daiichi Sankyo’s antibody-drug conjugate Enhertu scored its second approval in less than a week, this time for a subset of lung cancer patients.

Enhertu received accelerated approval on Thursday to treat adults with unresectable or metastatic non-small cell lung cancer (NSCLC) whose tumors have activating HER2 (ERBB2) mutations, and who have already received a prior systemic therapy.

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J&J to re­move talc prod­ucts from shelves world­wide, re­plac­ing with corn­starch-based port­fo­lio

After controversially spinning out its talc liabilities and filing for bankruptcy in an attempt to settle 38,000 lawsuits, Johnson & Johnson is now changing up the formula for its baby powder products.

J&J is beginning the transition to an all cornstarch-based baby powder portfolio, the pharma giant announced on Thursday — just months after a federal judge ruled in favor of its “Texas two-step” bankruptcy to settle allegations that its talc products contained asbestos and caused cancer. An appeals court has since agreed to revisit that case.

CSL is gathering its four business units under a unified brand identity strategy (Credit: CSL company site)

CSL brings Se­qirus, Vi­for un­der par­ent um­brel­la brand in iden­ti­ty re­vamp

CSL is gathering its brands under the family name umbrella, renaming its vaccine and newly acquired nephrology specialty businesses with the parent initials.

CSL Seqirus and CSL Vifor join CSL Plasma and CSL Behring as the four now uniformly branded business units of the global biopharma. The Seqirus vaccine division was formed in 2015 with the combination of bioCSL and its purchase of Novartis’ flu vaccine business. CSL picked up Vifor Pharma late last year in an $11.7 billion deal for the nephrology, iron deficiency and cardio-renal drug developer.

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