UNC re­searchers re­port a new way to charge CAR-T against sol­id tu­mors

When re­searchers first start­ed putting CAR-T cells in­to can­cer pa­tients in the 1990s, the cells didn’t do very much. They swam around in the blood, killing very lit­tle of what they were meant to kill, be­fore dy­ing a qui­et death some months lat­er.

There were sev­er­al big rea­sons for the fail­ures. Re­searchers at first picked the wrong dis­eases, go­ing af­ter sol­id tu­mors that, it turned out, were unique­ly adept at keep­ing out T cells. And they didn’t even re­al­ly know which parts of these tu­mors were the best to aim at.

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