Ver­sant-backed Chi­nook gets a $65M launch round for its dis­cov­ery quest in a resur­gent kid­ney field

Ver­sant is once again step­ping off the beat­en track in biotech to see if they can blaze a trail of their own in a field that has looked too thorny to many in­vestors for years.

The ven­ture group and their part­ners at Ap­ple Tree are bring­ing their lat­est cre­ation out of stealth mode to­day. Born in Ver­sant’s In­cep­tion Sci­ences’ Chi­nook Ther­a­peu­tics is bet­ting that its pre­clin­i­cal take on kid­ney dis­ease can get an ear­ly lead among the com­pa­nies start­ing up in the field.

Head­ed by Er­ic Dob­meier, who left his post as COO of Seat­tle Ge­net­ics to take up the life of a biotech en­tre­pre­neur, Chi­nook is pur­su­ing a pipeline of pre­clin­i­cal pro­grams born in the be­lief that a bet­ter un­der­stand­ing of bi­ol­o­gy, new tech tools and a sup­port­ive FDA of­fer­ing ac­cel­er­at­ed path­ways is all a new recipe for suc­cess in the pur­suit of pre­ci­sion med­i­cines fo­cused on unique pa­tient pop­u­la­tions.

We don’t know what these drugs are, or specif­i­cal­ly what they are tar­get­ing, yet. But Ver­sant and the Chi­nook team be­lieve they will be in the clin­ic in 2021 when it can say a lot more.

For now, they’re hap­py to stay fo­cused on a resur­gent field lit­tered with the corpses of failed drugs.

Jer­el Davis Ver­sant

“It re­minds me of NASH and liv­er dis­ease 4-plus years ago,” says Ver­sant man­ag­ing di­rec­tor Jer­el Davis. Now phar­ma has be­gun set­ting up its own groups to tack­le the field, and he wants in on the ground floor.

Dob­meier has a $65 mil­lion A round and a team of 25 to lead for­ward. You may re­call that Dob­meier’s first biotech gig out of Seat­tle Ge­net­ics was with a com­pa­ny called Sil­ver­back. But they ex­pe­ri­enced an ear­ly set­back, says the biotech ex­ec, and he ex­it­ed the com­pa­ny — join­ing Chi­nook back in April.

Ver­sant and Ap­ple Tree were joined by Sam­sara Bio­Cap­i­tal on the launch round.

The Ver­sant team has made a habit of try­ing to get an ear­ly jump on emerg­ing R&D fields. That strat­e­gy, which in­volves cre­at­ing dis­cov­ery teams in some off-beat places like Van­cou­ver, in­clud­ed their re­gen­er­a­tive stem cell play Blue­Rock, which Bay­er just bought out at a uni­corn val­u­a­tion.

They’re fol­low­ing in the foot­steps of com­pa­nies like Goldfinch, a Third Rock start­up in the class of 2016 that re­cent­ly teamed with Gilead on its ap­proach to kid­ney dis­ease. That heav­i­ly back-end­ed deal helped in­spire Ver­sant to go deep­er. An­oth­er com­pa­ny in the field is Rea­ta, which was once al­lied with Ab­b­Vie — ahead of a clin­i­cal im­plo­sion that they’ve been work­ing to re­cov­er from. 

A New Fron­tier: The In­ner Ear

What happens when a successful biotech venture capitalist is unexpectedly diagnosed with a chronic, life-disrupting vertigo disorder? Innovation in neurotology.

That venture capitalist was Jay Lichter, Ph.D., and after learning there was no FDA-approved drug treatment for his condition, Ménière’s disease, he decided to create a company to bring drug development to neurotology. Otonomy was founded in 2008 and is dedicated to finding new drug treatments for the hugely underserved community living with balance and hearing disorders. Helping patients like Jay has been the driving force behind Otonomy, a company heading into a transformative 2020 with three clinical trial readouts: Phase 3 in Ménière’s disease, Phase 2 in tinnitus, and Phase 1/2 in hearing loss. These catalysts, together with others in the field, highlight the emerging opportunity in neurotology.
Otonomy is leading the way in neurotology
Neurotology, or the treatment of inner ear neurological disorders, is a large and untapped market for drug developers: one in eight individuals in the U.S. have moderate-to-severe hearing loss, tinnitus or vertigo disorders such as Ménière’s disease.1 With no FDA-approved drug treatments available for these conditions, the burden on patients—including social anxiety, lower quality of life, reduced work productivity, and higher rates of depression—can be significant.2, 3, 4

Joe Jimenez, Getty

Ex-No­var­tis CEO Joe Jimenez is tak­ing an­oth­er crack at open­ing a new chap­ter in his ca­reer — and that in­cludes a new board seat and a $250M start­up

Joe Jimenez is back.

The ex-CEO of Novartis has taken a board seat on Century Therapeutics, the Versant and Bayer-backed startup focused on coming up with a brand new twist on cell therapies for cancer — a field where Jimenez made his mark backing the first personalized CAR-T approved for use.

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Can we make the an­tibi­ot­ic mar­ket great again?

The standard for-profit model in drug development is straightforward. Spend millions, even billions, to develop a medicine from scratch. The return on investment (and ideally a tidy profit) comes via volume and/or price, depending on the disease. But the string of big pharma exits and slew of biotech bankruptcies indicate that the model is sorely flawed when it comes to antibiotics.

The industry players contributing to the arsenal of antimicrobials are fast dwindling, and the pipeline for new antibiotics is embarrassingly sparse, the WHO has warned. Drugmakers are enticed by greener pastures, compared to the long, arduous and expensive path to antibiotic approval that offers little financial gain as treatments are typically priced cheaply, and often lose potency over time as microbes grow resistant to them.

Top Har­vard chemist caught up in FBI’s 'T­hou­sand Tal­ents' drag­net, ac­cused of ly­ing about Chi­nese con­nec­tions, pay

The FBI’s probe into the alleged theft of R&D secrets by Chinese authorities has drawn Harvard’s top chemist into its net.

The agency accused Charles M. Lieber, who chairs the university’s chemistry and chemical biology department, with lying about his involvement in China’s Thousand Talents campaign, which was established as a way of drawing in innovators from around the world. And the scientist, 60, was charged with making false statements about his ties to China.

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Eye­ing a trio of tri­al ini­ti­a­tions, Jim Wilson's gene ther­a­py start­up woos Bruce Gold­smith from Deer­field as CEO

Passage Bio — Jim Wilson’s self-described “legacy company” — has wooed a seasoned biotech executive to steer the clinical entry of its first three gene therapy programs.

Bruce Goldsmith jumps to the helm of Passage after a brief CEO stint at Civetta, a cancer-focused startup he helped launch while a venture partner at Deerfield. He takes over from OrbiMed partner and interim chief Stephen Squinto, who will now lead the R&D team.

The FTC and New York state ac­cuse Mar­tin Shkre­li of run­ning a drug mo­nop­oly. They plan to squash it — and per­ma­nent­ly ex­ile him

Pharma bro Martin Shkreli was jailed, publicly pilloried and forced to confront some lawmakers in Washington riled by his move to take an old generic and move the price from $17.50 per pill to $750. But through 4 years of controversy and public revulsion, his company never backed away from the price — left uncontrolled by a laissez faire federal policy on a drug’s cost.

Now the FTC and the state of New York plan to pry his fingers off the drug once and for all and open it up to some cheap competition. And their lawsuit is asking that Shkreli — with several years left on his prison sentence — be banned permanently from the pharma industry.

UP­DAT­ED: Ac­celeron res­ur­rects block­buster hopes for so­tater­cept with pos­i­tive PhII — and shares rock­et up

Acceleron $XLRN says that its first major trial readout of 2020 is a success.

In a Phase II study of 106 patients with pulmonary arterial hypertension (PAH), Acceleron’s experimental drug sotatercept hit its primary endpoint: a significant reduction in pulmonary vascular resistance. The drug also met three different secondary endpoints, including the 6-minute walking test.

“We’re thrilled to report such positive topline results from the PULSAR trial,” Acceleron CEO Habib Dable said in a statement. The company said in a conference call they plan on discussing a Phase III trial design with regulators.

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Short at­tack­er Sahm Ad­ran­gi draws crosshairs over a fa­vorite of Sanofi’s new CEO — with PhII da­ta loom­ing

Sahm Adrang Kerrisdale

Kerrisdale chief Sahm Adrangi took a lengthy break from his series of biotech short attacks after his chief analyst in the field pulled up stakes and went solo. But he’s making a return to drug development this morning, drawing crosshairs over a company that’s one of new Sanofi CEO Paul Hudson’s favorite collaborators.

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Amber Saltzman (Ohana)

Flag­ship's first ven­ture of 2020 is out, and it's all about sperm

A couple years ago, Amber Salzman got a call as she was returning East full-time after a two-year stint running a gene therapy company in California.

It was from someone at Flagship Pioneering, the deep-pocketed biotech venture firm. They had a new company with a new way of thinking about sperm. It had been incubating for over a year, and now they wanted her to run it.

“It exactly fit,” Salzman told Endpoints News. “I just thought I had to do something.”