Ver­sant backs new ap­proach to gam­ma delta T cells, co-leads Lava's $18.9M round

With im­muno-on­col­o­gy dom­i­nat­ing pipelines these days, the field of gam­ma delta T cells — once a tiny area of study — is gain­ing some steam. The newest play­er to the space is La­va Ther­a­peu­tics, a tiny biotech in the Nether­lands that just got $18.9 mil­lion co-led by Ver­sant Ven­tures and Gilde Health­care to de­vel­op its un­usu­al take.

Gam­ma delta T cells are tar­gets for re­search for their po­ten­tial to in­vade tis­sue and per­haps be bet­ter at in­fil­trat­ing tu­mors, which would be a ground­break­er in im­muno-on­col­o­gy. Where CAR-Ts have proved ef­fec­tive in blood can­cers, it’s been a chal­lenge get­ting them in­to tu­mors And while check­point ther­a­pies like Keytru­da and Op­di­vo re­quire an en­vi­ron­ment with a heavy mu­ta­tion load to be ef­fec­tive, gam­ma delta cells – at least in the pre­clin­i­cal work — don’t. Gam­ma delta cells have the es­sen­tial prop­er­ties to get in­side tu­mors to do their work.

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