Ver­sant de­buts Ridge­line's start­up #4, armed with $30M and al­ter­na­tive TCR cell ther­a­pies for sol­id tu­mors

For all the it­er­a­tions and ad­vances in TCR ther­a­pies for can­cer, any ex­per­i­men­tal treat­ments in­volv­ing T cell re­cep­tors share one trait: By de­f­i­n­i­tion, they on­ly rec­og­nize anti­gens pre­sent­ed as pep­tides on the ma­jor his­to­com­pat­i­bil­i­ty com­plex (MHC) on cells.

Ver­sant reck­ons it’s time to ex­pand the ar­se­nal. With $30 mil­lion in ini­tial fund­ing, its Ridge­line Dis­cov­ery En­gine in Switzer­land has been work­ing on a non-pep­tidic ap­proach that it says has tu­mor-ag­nos­tic po­ten­tial, es­pe­cial­ly in sol­id tu­mors. They’ve named it Mat­ter­horn, af­ter a Swiss moun­tain as they did with the three oth­er com­pa­nies that have emerged from the Basel-based in­cu­ba­tor.

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