Ver­tex and Covid-19 spell the end for Savara's CF pro­gram

It’s a tough mar­ket for cys­tic fi­bro­sis these days. Just ask Savara.

Two years ago, the Austin-based biotech de­signed and launched a tri­al to test whether their lead GM-CSF drug mol­gradex can re­duce lung in­fec­tion in adult CF pa­tients. At the time, Ver­tex on­ly had 3 CF drugs, they on­ly cov­ered a por­tion of pa­tients, and they weren’t al­ways in­cred­i­bly ef­fec­tive. Then last year came Trikaf­ta, the ex­pen­sive triple-com­bi­na­tion that had sig­nif­i­cant ben­e­fits for around 90% of pa­tients.

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