With a 'monopoly' on gly­co­pro­teomics, In­ter­Venn rais­es $34M to push can­cer di­ag­nos­tic in­to the clin­ic, woos Il­lu­mi­na BD ex­ec

For a few years now, ear­ly de­tec­tion of can­cer has been the sex­i­est top­ic in all of di­ag­nos­tics. With bil­lions of VC dol­lars poured in­to the pur­suit of tests to sniff out tu­mors ear­ly, the field is full of new ap­proach­es that promise to ac­cu­rate­ly pick up traces of can­cer, when pa­tients are more like­ly to be cured. But amid all the -omics — rang­ing from next-gen­er­a­tion ge­net­ic se­quenc­ing to high-through­put pro­tein screen­ing — one par­tic­u­lar type of mol­e­cule is al­ways ab­sent.

Al­do Car­ras­coso

What’s miss­ing is an analy­sis of pro­tein gly­co­sy­la­tion, ac­cord­ing to In­ter­Venn Bio­sciences, which has just raised $34 mil­lion to com­mer­cial­ize its first di­ag­nos­tics.

While In­ter­Venn may lack the glam­our of big-mon­ey out­fits such as Grail (now ac­quired by Il­lu­mi­na), Thrive, Kar­ius, Seer and Freenome, the South San Fran­cis­co-based com­pa­ny boasts of two star founders who’ve spent years to un­earth the in­tri­ca­cies of gly­co­bi­ol­o­gy: Car­olyn Bertozzi of Stan­ford and Car­l­i­to Le­bril­la of UC Davis.

It’s al­so re­cruit­ed a new chief busi­ness of­fi­cer, John Leite, from di­ag­nos­tics gi­ant Il­lu­mi­na to scout deals for some of the 24 dif­fer­ent tests in the port­fo­lio.

In­ter­Venn CEO Al­do Car­ras­coso, whose en­tre­pre­neur­ial ef­forts have pre­vi­ous­ly re­volved around busi­ness man­age­ment, dig­i­tal me­dia and blockchain, crossed paths with the sci­en­tists af­ter his cousin, fol­low­ing his moth­er and a close rel­a­tive, suc­cumbed to breast can­cer in 2016. The fam­i­ly tried every type of se­quenc­ing to no avail. The in­tense frus­tra­tion in un­der­stand­ing what’s go­ing on even­tu­al­ly led him to Le­bril­la’s lab, where he took a blood test.

He wait­ed a few hours for the blood to be processed by the mass spec­trom­e­ter. Then he was asked to come back in 12 months.

Car­l­i­to Le­bril­la

“I said, what do you mean come back in 12 months?” Car­ras­coso re­called to End­points News. The stu­dents and post­docs need­ed the time to run through the da­ta, re­peat­ing the process a few hun­dred thou­sand times to iden­ti­fy spec­tral sig­na­tures.

He had an idea of how you can su­per­charge what they were do­ing and trans­form the “in­sane process” with ar­ti­fi­cial in­tel­li­gence — a re­cur­rent neur­al net­work to be spe­cif­ic — and Le­bril­la took in­ter­est. The next year was spent build­ing a hand-cu­rat­ed dataset of gly­co­pro­teomics and us­ing it to train their first neur­al net­work.

The re­sult­ing al­go­rithm could spit out re­sults in 12 min­utes, some­times even 12 sec­onds.

John Leite

“That was the biggest bot­tle­neck for Car­l­i­to Le­bril­la and Car­olyn Bertozzi,” Car­ras­coso said. “The abil­i­ty to man­age the im­mense in­for­ma­tion that gly­co­pro­teomics gen­er­ate. It’s just over­whelm­ing for sci­en­tists.”

Through run­ning sam­ples for bio­phar­ma, hos­pi­tal and aca­d­e­m­ic clients, In­ter­Venn has dis­cov­ered bio­mark­ers that formed the ba­sis of 24 di­ag­nos­tics. In ear­ly 2021 they hope to com­plete en­roll­ment of a tri­al to com­pare its pan­el, VO­CAL, against the wide­ly used CA 125.

Af­ter that comes a slew of tests for re­nal, lung, liv­er, prostate, pan­cre­at­ic, na­sopha­ryn­geal, col­orec­tal can­cer and oth­ers, all con­sist­ing of dis­tinct sets of gly­copep­tides. In­ter­Venn al­so sees po­ten­tial ap­pli­ca­tion of its tech in im­muno-on­col­o­gy, where it may help drug de­vel­op­ers iden­ti­fy the pa­tients who would ben­e­fit from ther­a­pies that to­day on­ly helps 20% to 30% of pa­tients.

Er­win Es­ti­gar­rib­ia

“That’s some­thing that to­day doesn’t ex­ist,” COO Er­win Es­ti­gar­rib­ia, a vet­er­an of the di­ag­nos­tics space, said.

The re­al test lies ahead. With­out for­mal FDA ap­proval, In­ter­Venn’s pan­els must be processed cen­tral­ly at its San Fran­cis­co fa­cil­i­ty. But there’s a plan to ex­pand the over­sub­scribed ser­vice, not just by ex­pand­ing ca­pac­i­ty but ob­tain­ing reg­u­la­to­ry clear­ance to al­low oth­ers to run their di­ag­nos­tics, com­plete with a “plat­form ag­nos­tic” soft­ware that can han­dle da­ta from any mass spec­trom­e­ter. With the new cash com­ing in from Anzu Part­ners, Genoa Ven­tures, Am­pli­fy Part­ners, True Ven­tures, Xer­aya Cap­i­tal and the Oj­jeh Fam­i­ly, Car­ras­coso ex­pects the head­count to grow dra­mat­i­cal­ly from the cur­rent 50.

But for now, In­ter­Venn is con­tent oc­cu­py­ing what the CEO de­scribes as a mo­nop­oly.

“I wait for the day that there is an­oth­er In­ter­Venn,” he said. “But we’ve been search­ing for years. There hasn’t.”

Scoop: Boehringer qui­et­ly shut­ters a PhII for one of its top drugs — now un­der re­view

Boehringer Ingelheim has quietly shut down a small Phase II study for one of its lead drugs.

The private pharma player confirmed to Endpoints News that it had shuttered a study testing spesolimab as a therapy for Crohn’s patients suffering from bowel obstructions.

A spokesperson for the company tells Endpoints:

Taking into consideration the current therapeutic landscape and ongoing clinical development programs, Boehringer Ingelheim decided to discontinue our program in Crohn’s disease. It is important to note that this decision is not based on any safety findings in the clinical trials.

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Vas Narasimhan (Photographer: Jason Alden/Bloomberg via Getty Images)

No­var­tis de­tails plans to axe 8,000 staffers as Narasimhan be­gins sec­ond phase of a glob­al re­org

We now know the number of jobs coming under the axe at Novartis, and it isn’t small.

The pharma giant is confirming a report from Swiss newspaper Tages-Anzeiger that it is chopping 8,000 jobs out of its 108,000 global staffers. A large segment will hit right at company headquarters in Basel, as CEO Vas Narasimhan axes some 1,400 of a little more than 11,000  jobs in Switzerland.

The first phase of the work is almost done, the company says in a statement to Endpoints News. Now it’s on to phase two. In the statement, Novartis says:

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Lina Gugucheva, NewAmsterdam Pharma CBO

Phar­ma group bets up to $1B-plus on the PhI­II res­ur­rec­tion of a once dead-and-buried LDL drug

Close to 5 years after then-Amgen R&D chief Sean Harper tamped the last spade of dirt on the last broadly focused CETP cholesterol drug — burying their $300 million upfront and the few remaining hopes for the class with it — the therapy has been fully resurrected. And today, the NewAmsterdam Pharma crew that did the Lazarus treatment on obicetrapib is taking another big step on the comeback trail with a €1 billion-plus regional licensing deal, complete with close to $150 million in upfront cash.

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How pre­pared is bio­phar­ma for the cy­ber dooms­day?

One of the largest cyberattacks in history happened on a Friday, Eric Perakslis distinctly remembers.

Perakslis, who was head of Takeda’s R&D Data Sciences Institute and visiting faculty at Harvard Medical School at the time, had spent that morning completing a review on cybersecurity for the British Medical Journal. Moments after he turned it in, he heard back from the editor: “Have you heard what’s going on right now?”

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(AP Photo/Gemunu Amarasinghe)

Some phar­ma com­pa­nies promise to cov­er abor­tion-re­lat­ed trav­el costs — while oth­ers won't go that far yet

As the US Department of Health and Human Services promises to support the millions of women who would now need to cross state lines to receive a legal abortion, a handful of pharma companies have said they will pick up employees’ travel expenses.

GSK, Sanofi, Johnson & Johnson, BeiGene, Alnylam and Gilead have all committed to covering abortion-related travel expenses just four days after the Supreme Court overturned Roe v. Wade and revoked women’s constitutional right to an abortion.

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Aurobindo Pharma co-founders P. V. Ram Prasad Reddy (L) and K. Nityananda Reddy

Au­robindo Phar­ma re­ceives warn­ing let­ter from In­di­a's SEC fol­low­ing more FDA ques­tion marks

Indian-based generics manufacturer Aurobindo Pharma has been in the crosshairs of the FDA for several years now, but the company is also attracting attention from regulators within the subcontinent.

According to the Indian business news site Business Standard, a warning letter was sent to the company from the Securities Exchange Board of India, or SEBI.

The letter is related to disclosures made by the company on an ongoing FDA audit of the company’s Unit-1 API facility in Hyderabad, India as well as observations made by the US regulator between 2019 and 2022.

New Charles River Laboratories High Quality (HQ) Plasmid DNA Centre of Excellence at Bruntwood SciTech’s Alderley Park in Cheshire, United Kingdom. (Charles River)

Charles Riv­er Lab­o­ra­to­ries to start cell and gene ther­a­py man­u­fac­tur­ing at UK site in Sep­tem­ber

While Massachusetts-based Charles River Laboratories has been on an acquisition spree, they are not against planting their flag. The latest move by the company sees them crossing the pond to establish a manufacturing site in the UK.

The company on Tuesday opened its cell and gene therapy manufacturing center at Bruntwood SciTech’s Alderley Park in Cheshire, United Kingdom. The expansion follows Charles River’s acquisition of Cognate BioServices and Cobra Biologics in 2021 for $875 million. Cognate is a plasmid DNA, viral vector and cell therapy CDMO.

Bristol Myers Squibb (Alamy)

CVS re­sumes cov­er­age of block­buster blood thin­ner af­ter price drop fol­lows Jan­u­ary ex­clu­sion

Following some backlash from the American College of Cardiology and patients, Bristol Myers Squibb and Pfizer lowered the price of their blockbuster blood thinner Eliquis, thus ensuring that CVS Caremark would cover the drug after 6 months of it being off the major PBM’s formulary.

“Because we secured lower net costs for patients from negotiations with the drug manufacturer, Eliquis will be added back to our template formularies for the commercial segment effective July 1, 2022, and patient choices will be expanded,” CVS Health said in an emailed statement. “Anti-coagulant therapies are among the non-specialty products where we are seeing the fastest cost increases from drug manufacturers and we will continue to push back on unwarranted price increases.”

#Can­nes­Lions2022: Con­sumer health ex­ecs call on agen­cies to in­volve pa­tients in cre­ative process

CANNES — When Tamara Rogers joined GSK back in 2018, “science was king and R&D were the gods.” Now the global chief marketing officer of consumer healthcare wants to make room for another supreme being: the consumer.

As health and wellness becomes more relevant to consumers amid the pandemic, four health-focused executives called on marketers to involve patients in their creative process in a panel discussion at the Cannes Lions advertising creativity festival.

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