With loom­ing su­per­bug cri­sis, Iterum miss­es in a key an­tibi­ot­ic tri­al — and its shares tum­ble

A raft of an­tibi­ot­ic mak­ers have crashed and burned re­cent­ly de­spite get­ting their drugs across the fin­ish line. Iterum Ther­a­peu­tics hopes that its lead drug su­lopen­em, which has an out­pa­tient fo­cus in ad­di­tion to hos­pi­tals and a plan to tar­get ar­eas with the high­est lev­els of drug-re­sis­tant in­fec­tions, will avert some of those re­im­burse­ment chal­lenges. How­ev­er, the com­pa­ny has now stum­bled in a late-stage study, di­min­ish­ing its shot at FDA ap­proval it first re­quires.

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