$33M in hand, Rigontec opens an of­fice in Cam­bridge and sets sights on its first im­muno-on­col­o­gy tri­al

The Ger­man start­up Rigontec has nailed an ad­di­tion­al $16.5 mil­lion in fi­nanc­ing, dou­bling their Se­ries A as the RNA up­start opens a new of­fice in Cam­bridge, MA and preps for its first clin­i­cal study in the red-hot im­muno-on­col­o­gy are­na ear­ly next year.

The biotech is a pi­o­neer of the RIG-I path­way, look­ing to ramp up an im­mune sys­tem at­tack on tu­mor cells by stick­ing with a route that has been at­tract­ing at­ten­tion for the role it plays in the in­nate im­mune sys­tem. And the com­pa­ny owes a lot to the ear­ly re­search of Gunter Hart­mann at the Uni­ver­si­ty of Bonn, who stud­ied how RIG-I works nat­u­ral­ly in ac­ti­vat­ing an at­tack on vi­ral pathogens.

The com­pa­ny is run by Chris­t­ian Schet­ter, a biotech vet who has had se­nior po­si­tions at a cou­ple of de­vel­op­ers; Co­ley Phar­ma­ceu­ti­cals, where he was a se­nior vice pres­i­dent, and Neovii Biotech, where he was CEO un­til 2014. Dur­ing his ca­reer, he spent years study­ing the role of toll-like re­cep­tors in trig­ger­ing an im­mune re­sponse, but in RIG-I Schet­ter be­lieves he’s found a path­way that will be much more ef­fi­cient for de­vel­op­ing a safe and more ef­fec­tive im­munother­a­py.

The key here, he tells me, is de­vel­op­ing a “high­ly spe­cif­ic ac­ti­va­tor,” trig­ger­ing a nat­ur­al killer cell re­sponse to tu­mor cells while then me­di­at­ing “longterm im­mune mem­o­ry against tu­mor cells.” The op­por­tu­ni­ty in can­cer is fair­ly ob­vi­ous, says the CEO, with a chance to try out new ap­proach­es for check­point com­bos and oth­er match ups — a space where new deals keep com­ing at a steady pace. But he’s al­so map­ping plans for a sec­ond pipeline for in­fec­tious dis­eases, where he says the same tech can have a big im­pact.

The new fund­ing brings the to­tal raised at Rigontec since it was found­ed in ear­ly 2014 to just about $33 mil­lion. The com­pa­ny has about 15 staffers now, says the CEO, and will prob­a­bly see that grow to about 20-25 by the end of next year.

Their syn­di­cate in­cludes Boehringer In­gel­heim Ven­ture Fund, For­bion Cap­i­tal Part­ners, High-Tech Grün­der­fonds, NRW.BANK, MP Health­care Ven­ture Man­age­ment, Sun­stone Cap­i­tal and Welling­ton Part­ners Life Sci­ences.

BiTE® Plat­form and the Evo­lu­tion To­ward Off-The-Shelf Im­muno-On­col­o­gy Ap­proach­es

Despite rapid advances in the field of immuno-oncology that have transformed the cancer treatment landscape, many cancer patients are still left behind.1,2 Not every person has access to innovative therapies designed specifically to treat his or her disease. Many currently available immuno-oncology-based approaches and chemotherapies have brought long-term benefits to some patients — but many patients still need other therapeutic options.3

Gilead re­leas­es an­oth­er round of murky remde­sivir re­sults

A month after the NIH declared the first trial on remdesivir in Covid-19 a success, Gilead is out with new results on their antiviral. But although the study met one of its primary endpoints, the data are likely to only add to a growing debate over how effective the drug actually is.

In a Phase III trial, patients given a 5-day dose of remdesivir were 65% more likely to show “clinical improvement” compared to an arm given standard-of-care. The trial, though, gave little indication for whether the drug had an impact on key endpoints such as survival or time-to-recovery. And in a surprising twist, a 10-day dosing arm of remdesivir didn’t lead to a statistically significant improvement over standard of care.

Endpoints News

Keep reading Endpoints with a free subscription

Unlock this story instantly and join 82,000+ biopharma pros reading Endpoints daily — and it's free.

Fangliang Zhang (Imaginechina via AP Images)

The big mon­ey: Poised to make drug R&D his­to­ry, a Chi­na biotech un­veils uni­corn rac­ing am­bi­tions in a bid to raise $350M-plus on Nas­daq

Almost exactly three years after Shanghai-based Legend came out of nowhere to steal the show at ASCO with jaw-dropping data on their BCMA-targeted CAR-T for multiple myeloma, the little player with Big Pharma connections is taking a giant step toward making it big on Wall Street. And this time they want to seal the deal on a global rep after staking out a unicorn valuation in what’s turned out to be a bull market for biotech IPOs — in the middle of a pandemic.

Endpoints Premium

Premium subscription required

Unlock this article along with other benefits by subscribing to one of our paid plans.

Len Schleifer (left) and George Yancopoulos, Regeneron (Vimeo)

Eyes on he­mo­phil­ia prize, Re­gen­eron adds a $100M wa­ger on joint de­vel­op­ment cam­paign with In­tel­lia

When George Yancopoulos first signed up Intellia to be its CRISPR/Cas9 partner on gene editing projects 4 years ago, the upstart smartly ramped up its IPO at the same time. Today, Regeneron $REGN is coming back in, adding $100 million in an upfront fee and equity to significantly boot up a whole roster of new development projects.

And they’re highlighting some clinical hemophilia research plans in the process.

Endpoints News

Keep reading Endpoints with a free subscription

Unlock this story instantly and join 82,000+ biopharma pros reading Endpoints daily — and it's free.

Jean-Jacques Bienaimé, BioMarin chairman and CEO

Bio­Marin holds the line on bleeds with 4-year val­rox up­date on he­mo­phil­ia A — but what's this about an­oth­er de­cline in Fac­tor 8 lev­els?

BioMarin has posted some top-line results for their 4-year followup on the most advanced gene therapy for hemophilia A — extending its streak on keeping a handful of patients free of bleeds and off Factor VIII therapy, but likely stirring fresh worries over a continued drop in Factor VIII levels.

We just don’t know how big a drop.

We’ll see more data when the results are presented at the World Federation of Hemophilia in a couple of weeks. But in a statement out Sunday night, BioMarin $BMRN reported that none of the patients required Factor VIII treatment, adding:

Endpoints News

Keep reading Endpoints with a free subscription

Unlock this story instantly and join 82,000+ biopharma pros reading Endpoints daily — and it's free.

As­traZeneca trum­pets the 'mo­men­tous' da­ta they found for Tagris­so in an ad­ju­vant set­ting for NSCLC — but many of the ex­perts aren’t cheer­ing along

AstraZeneca is rolling out the big guns this evening to provide a salute to their ADAURA data on Tagrisso at ASCO.

Cancer R&D chief José Baselga calls the disease-free survival data for their drug in an adjuvant setting of early stage, epidermal growth factor receptor-mutated NSCLC patients following surgery “momentous.” Roy Herbst, the principal investigator out of Yale, calls it “transformative.”

Endpoints News

Keep reading Endpoints with a free subscription

Unlock this story instantly and join 82,000+ biopharma pros reading Endpoints daily — and it's free.

Iterum's fu­ture looks un­cer­tain, af­ter lead an­tibi­ot­ic fails con­sec­u­tive piv­otal stud­ies

While the market for antibiotics remains in tatters — unlike many of its bankrupt (or at the brink of bankruptcy) peers — Iterum is suffering not because its antibiotic isn’t selling, but because the compound has now failed back-to-back late-stage studies.

The experimental drug, sulopenem, was designed to tackle drug-resistant infections with an outpatient focus (in addition to hospitals), to avert those reimbursement challenges that incentivize hospitals to prescribe cheaper, generic broad-spectrum antibiotics.

Covid-19 roundup: Did in­sid­ers cash in on pos­i­tive news re­port about Gilead be­fore pub­li­ca­tion?

A series of bullish trades on Gilead options just before the release of a favorable news story is raising questions among regulatory experts, Reuters reported.

On April 16, just hours before STAT published anecdotes from a Chicago hospital that served as one of the clinical sites to test Gilead’s remdesivir in Covid-19 patients, the California-based company’s shares were trading at around $75. Four large blocks of options were purchased for about $1.5 million each, betting that the stock would rise beyond that to as much as $87.5 by mid-August.

Endpoints News

Keep reading Endpoints with a free subscription

Unlock this story instantly and join 82,000+ biopharma pros reading Endpoints daily — and it's free.

Roche nabs front­line OK for Avastin/Tecen­triq in com­mon liv­er can­cer, best­ing an old Bay­er drug

For the first time in 12 years, the FDA has approved a new frontline treatment for the most common form of liver cancer.

The agency okayed a combination of Roche’s anti-VEGF antibody Avastin and their immunotherapy Tecentriq for patients with unresectable or metastatic hepatocellular carcinoma (HCC). The approval comes two weeks after Roche and their big biotech sub Genentech published Phase III results showing the combo improved both progression-free survival and, crucially, helped patients live longer than the long-running standard-of-care, Bayer’s Nexavar.