Penn researchers find a way through the labyrinth keeping CAR-T from solid tumors
Blood vessels are supposed to act like trees, pumping in oxygen tissues need to grow and immune cells required to clear out pathogens. But in tumors, the forest can go a bit haywire. Vessels grow prodigiously and bulge and twist at abrupt points, making it difficult to even tell what’s a vein and what’s an artery. It starts to look less like a forest and more like a gnarled root floor. “A disorganized labyrinth,” one oncologist has called it.