Marino Garcia, Dianthus CEO

5AM, Avid­i­ty, Fi­deli­ty lead $100M in­fu­sion in­to next-gen, tar­get­ed com­ple­ment ap­proach

When the FDA first ap­proved Alex­ion’s Soliris — then eculizum­ab — in 2007, ex­perts cel­e­brat­ed how the first-of-its-kind drug trans­formed the way physi­cians could treat a rare dis­ease called parox­ys­mal noc­tur­nal he­mo­glo­bin­uria.

As Soliris racked up more land­mark OKs, the C5 in­hibitor al­so be­came a wild­ly suc­cess­ful fran­chise for the com­pa­ny, spurring block­buster sales that led to a fol­low-on drug and a $39 bil­lion buy­out by As­traZeneca while in­spir­ing new play­ers to jump in­to the com­ple­ment space.

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