Analyst offers Amgen a boost for its rival anti-BCMA BiTE, blemishing GSK as well as CAR-T rivals Celgene and bluebird
Baird’s Brian Skorney is giving Amgen a thumbs up today for a snapshot of human data from its anti-BCMA BiTE program AMG 420, possibly causing a few headaches among its rivals in the closely watched space.
In a note out at mid-day, Skorney wrote:
Over the weekend, initial clinical data for AMG 420 were presented at the Myeloma 2018 meeting. Notably, in the high dose group there were five patients with stringent complete responses (sCR). This included four MRD-negative patients. The presentation indicated that four of the patients had responses ongoing > 10 months. We think this compares favorably to Celgene/bluebird’s CART-BCMA program, bb2121, which has a 50% CR/sCR, 36.4% VGPR and ORR of 95.5% and a median dOR of 10.8 months in 22 patients administered > 150 x 106. The antibody approach to targeting BCMA has, so far, been disappointing.
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