Roche/Genen­tech dou­bles down on tau, fronting $120M cash to al­ly on a 2-pronged strat­e­gy to fight Alzheimer’s

Af­ter butting up against re­peat­ed fail­ures on the amy­loid be­ta side of the R&D strat­e­gy for fight­ing Alzheimer’s, Roche is once again turn­ing to the run­ner-up tar­get that has been get­ting an in­creased fo­cus in the hopes of find­ing some­thing — any­thing — that can slow the progress of this dis­ease.

The terms of the deal in­clude $120 mil­lion up­front for UCB, plus po­ten­tial de­vel­op­ment and sales mile­stones, cost re­im­burse­ment and roy­al­ties to­tal­ing near­ly $2 bil­lion. UCB will fund and con­duct a proof-of-con­cept study in Alzheimer’s, and with the re­sults in hand, Genen­tech, a Roche sub­sidiary, can ei­ther re­turn the rights to UCB or push ahead in a dri­ve to the mar­ket.

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