Bris­tol My­er­s' CAR-T Breyanzi busts out a win in ear­li­er-line lym­phoma, po­ten­tial­ly crack­ing open an ex­pand­ed mar­ket

De­spite be­ing third to the field in B cell lym­phoma, Bris­tol My­ers Squibb has re­peat­ed­ly ar­gued its CAR-T Breyanzi could have the juice to over­take its old­er com­peti­tors. Go­ing in­to ear­li­er lines of ther­a­py may be the gold­en tick­et on that front, and now Breyanzi has a late-stage win to back up that ef­fort.

Bris­tol My­ers’s Breyanzi beat out physi­cians’-choice sal­vage ther­a­py fol­lowed by high-dose chemo and a stem cell trans­plant — what the drug­mak­er called a “gold stan­dard treat­ment” — in sec­ond-line pa­tients with re­lapsed or re­frac­to­ry large B cell lym­phoma, ac­cord­ing to topline da­ta from the Phase III TRANS­FORM study re­leased Thurs­day.

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