#ASCO17 highlights: Roche ushers early-stage bispecific into view; Agios, Celgene unveil more AG-221 data; Plenty more coming at ASCO
Roche has an early-stage T cell bispecific — which binds simultaneously to T cells and tumor cells — called CEA-TCB (RO6958688; RG7802) that it is bullish about. It released a very early look at Phase I data for ASCO, looking at monotherapy as well as a combo with its checkpoint Tecentriq. The data demonstrate: “In the monotherapy, out of 31 patients with mCRC treated with CEA-TCB doses of 60mg or above, 14 patients (45%) showed either partial response (n=2, 6%) or stable disease (n=12, 39%). For the combination, of 25 patients treated with doses of 5–160mg of CEA-TCB, 11 patients with MSS mCRC were treated at doses shown to induce tumour lesion inflammation (80 and 160 mg). Nine of these patients (82%) showed either a partial response (n=2, 18%) or stable disease (n=7, 64%) in this difficult-to-treat population.”
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