Shire writes off a shot at long-acting hemophilia drug after small study flops
When Shire took over Baxalta, it acquired a program in development that used the technology from nearby Lexington, MA-based Xenetic Biosciences to stretch SHP656 into a long-acting drug with the potential for once-weekly dosing, or less, for hemophilia A.
But it didn’t work. And Xenetic’s stock plunged 30%.
Xenetic $XBIO says that in a Phase I/II study, conjugating polysialic acid to therapeutic blood-clotting factors with its platform tech had the right pharmacokinetic profile for an extended half-life rFVIII product. But it didn’t fit the bill for once-weekly dosing.
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