Cara tries hard to spin the data, but key PhIIb pain study fails and shares slide south
Cara Therapeutics tried to spin the data in its favor, but all three doses of its lead drug CR845 flopped against a key endpoint on pain for osteoarthritis, including the high dose, leaving investigators trying to polish up other data sets as an indication of success.
The important data set that did work out was for patients with osteoarthritis of the hip who completed an 8-week course of the high 5 mg dose. But even that was not a home run, with a p-value on pain reduction of 0.043 compared to the placebo arm. For all OA hip and knee patients who completed high-dose therapy there was a failed p-value of 0.111.
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