A Third Rock-backed play­er charts a new course against tran­scrip­tion fac­tors. Do 'switch sites' hold the mag­ic sauce?

Long known for their role in guid­ing gene ex­pres­sion but con­sid­ered “un­drug­gable,” DNA bind­ing tran­scrip­tion fac­tors have long been a Holy Grail for drug de­vel­op­ers …

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