After Rova-T bust, AbbVie plans new solid tumor assault, licensing next-gen CAR-T tech from Calibr
After its disappointing Rova-T flop last month, AbbVie is shoring up its solid tumor bets with a freshly inked research deal that should elicit new strategies for tumor attack. This time, AbbVie is hoping to use potentially safer, next-gen CAR-Ts that have been cooking in the labs of a San Diego research institute for the past few years.
The pharma giant is buying an exclusive four-year license to tech developed at the California Institute for Biomedical Research — better known as Calibr — to interrogate some of its own cancer targets, including solid tumors. Calibr is bringing to the table a platform based on a “switchable” CAR-T cell. I talked with Travis Young, Calibr’s director of protein sciences, last Friday to find out what that actually means. Young tells me it’s about reducing toxicity and getting a more durable response from CAR-Ts, which are known to cause safety issues.
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