David Reese, Amgen R&D chief

Am­gen maps a PhI­II jour­ney for its lat­est great car­dio drug hope­ful. Can it suc­ceed this time?

Just a few days ago, Am­gen CEO Bob Brad­way tout­ed one of the com­pa­ny’s car­dio pro­grams for a drug called ol­pasir­an as one of the top drugs in the pipeline. And now Brad­way’s phar­ma gi­ant has tak­en the wraps off a de­tailed and up­dat­ed out­line of Phase II da­ta as it ex­plains its hopes for a ma­jor new ther­a­py in the sec­tor.

The siR­NA drug — orig­i­nal­ly pushed in­to the spot­light on the set­back of Am­gen’s part­nered drug ome­cam­tiv a cou­ple of years ago — es­sen­tial­ly wiped out all but small amounts of lipopro­tein(a) (Lp(a) lev­els in pa­tients suf­fer­ing from ath­er­o­scle­rot­ic car­dio­vas­cu­lar dis­ease.

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