An explosion of PD-1/L1 checkpoint studies is crowding the industry pipeline — and that’s a problem
WASHINGTON, DC — The Cancer Research Institute has been doing the math on the PD-1/L1 checkpoint pipeline, and you might not believe what we’re seeing now in terms of clinical research programs.
In a discussion here at the Society for Immunotherapy of Cancer meeting, Samir Khleif, an immuno-oncologist and SITC board member, laid out the numbers from the CRI.
With 5 checkpoints on the market, there are now 164 different checkpoint therapies being studied from the preclinical through late-stage phase. There are three more right now in Phase III — REGN-2810 from Sanofi/Regeneron, PDR001 from Novartis and INCSHR-1210 from Incyte/Jiangsu Hengrui — and 9 in Phase II.
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