Arndt Rolfs steps aside as Cen­to­gene CEO, with An­drin Os­wald named as his suc­ces­sor; João Sif­fert lands an­oth­er CEO post at De­sign Ther­a­peu­tics

Arndt Rolfs

→ There’s a change at the top at Ger­man rare dis­ease biotech Cen­to­gene. Arndt Rolfs de­cid­ed to step down as CEO, ef­fec­tive Tues­day, and Big Phar­ma vet An­drin Os­wald will re­place him start­ing Dec. 1. Os­wald, the del­e­gate for Covid-19 vac­cines and im­munother­a­pies for the fed­er­al gov­ern­ment of Switzer­land, re­cent­ly spent 4 years with the Bill & Melin­da Gates Foun­da­tion as di­rec­tor of life sci­ence in­dus­try en­gage­ment and part­ner­ships. He was al­so a busi­ness in­te­gra­tion ex­ec at GSK and di­vi­sion head of vac­cines & di­ag­nos­tics at No­var­tis.

Rolfs will stay as an ad­vi­sor dur­ing the tran­si­tion. Cen­to­gene and Evotec an­nounced an ex­pan­sion of their part­ner­ship in Au­gust that tar­gets Gauch­er dis­ease, the most com­mon lyso­so­mal stor­age dis­or­der.

João Sif­fert

→ Not even a month af­ter ex­it­ing stage left from a tee­ter­ing Abeona Ther­a­peu­tics, João Sif­fert is now at the helm of San Diego start­up De­sign Ther­a­peu­tics, which launched with a $43 mil­lion round in March and is geared to­ward de­gen­er­a­tive dis­eases brought about by nu­cleotide re­peat ex­pan­sions. Sif­fert, who was al­so Abeona’s head of R&D and CMO, was the head­lin­er in a mass ex­o­dus at the gene ther­a­py biotech that in­clud­ed 5 board mem­bers. Sif­fert will al­so be a board mem­ber at De­sign Ther­a­peu­tics, which was co-found­ed by Pratik Shah and Aseem Ansari and has a lead pro­gram that tar­gets Friedre­ich’s atax­ia.

→ In the process of de­vel­op­ing pro­grams for pem­phi­gus vul­garis and celi­ac dis­ease, Ger­man biotech Topas Ther­a­peu­tics has tapped Klaus Mar­tin as CEO, a tran­si­tion that ac­tu­al­ly took place in Au­gust af­ter the res­ig­na­tion of Timm Jessen but was re­leased nonethe­less this week. Mar­tin was pres­i­dent of Toron­to-based Apo­bi­ologix the last 2 years be­fore mak­ing the move to Topas. Among his oth­er stops, he was al­so CSO of Pol­phar­ma Bi­o­log­ics and led busi­ness de­vel­op­ment & li­cens­ing and port­fo­lio man­age­ment dur­ing his 8 years at San­doz.

→ Two new C-suite ex­ecs are on board at Vac­citech, the Ox­ford T cell vac­cine and im­munother­a­py play­er co-found­ed by Sarah Gilbert, with Meg Mar­shall com­ing on as CMO and Geor­gy Egorov as CFO. Mar­shall has con­sult­ed at Vac­citech since June and has held clin­i­cal re­search di­rec­tor­ships at Pfiz­er, Kite and Ky­owa Kirin. Egorov bounces to Vac­citech from Ex­sci­en­tia, an AI drug dis­cov­ery com­pa­ny al­so based in Ox­ford, spend­ing 2 years as their CFO and as a board mem­ber.

Chris­tine Heenan

Noubar Afeyan’s Flag­ship Pi­o­neer­ing has brought Chris­tine Heenan on board as se­nior part­ner and chief com­mu­ni­ca­tions of­fi­cer. A for­mer speech­writer and se­nior pol­i­cy an­a­lyst in the Clin­ton ad­min­is­tra­tion, Heenan found­ed and is pres­i­dent of the Claren­don Group, which has ad­vised the Broad In­sti­tute, the Bill and Melin­da Gates Foun­da­tion and Har­vard. Heenan has con­nec­tions to Har­vard, serv­ing as the uni­ver­si­ty’s VP of pub­lic af­fairs and com­mu­ni­ca­tions from 2008-15.

→ Af­ter David Main took the helm as pres­i­dent and CEO in Ju­ly, two more ex­ecs have joined Toron­to biotech Notch Ther­a­peu­tics, fo­cused on cre­at­ing al­lo­gene­ic T cell ther­a­pies from re­new­able stem cell sources. EVP, fi­nance and CFO Kam­ran Alam was in­ter­im CFO at In­ter­leukin Ther­a­peu­tics for a time af­ter the com­pa­ny merged with Aquinox Phar­ma­ceu­ti­cals, where he was an 8-year vet. Gre­go­ry Block, who steps in as SVP, cor­po­rate de­vel­op­ment, had just com­plet­ed a year-and-a-half run at Astel­las as their di­rec­tor of busi­ness de­vel­op­ment.

Mah­boob Rah­man

Mah­boob Rah­man, well-trav­eled in Big Phar­ma, has been in­stalled as CSO of Cy­to­Dyn, which hit a snag in Ju­ly to the tune of a refuse-to-file let­ter for its lead drug leron­limab in HIV. The drug is al­so in a Phase II tri­al for graft-ver­sus-host dis­ease and a Phase Ib/II tri­al for metasta­t­ic triple-neg­a­tive breast can­cer. An alum of Cen­to­cor/J&J, Pfiz­er and No­var­tis, Rah­man spent the last year as Mesoblast’s glob­al head of im­munol­o­gy de­vel­op­ment and phar­ma­covig­i­lance. He was al­so pres­i­dent and CMO at Glen­mark be­fore he made his way to Mesoblast.

Third Rock-backed Rheos Med­i­cines — fo­cused on the field of im­munome­tab­o­lism — has picked up Da­nia Rabah as CSO. Rabah hails from Bio­gen, where she served as head of drug dis­cov­ery in­cu­ba­tor, re­search and ear­ly de­vel­op­ment.

→ Cam­bridge, MA mi­cro­bio­me play­er Seres Ther­a­peu­tics con­tin­ues to fill out its lead­er­ship team, with David Ege join­ing as chief tech­nol­o­gy of­fi­cer and Jayne Gansler as chief peo­ple of­fi­cer. In April, Lisa von Moltke was named CMO of Seres, which mount­ed a Phase III come­back in the sum­mer for their C. dif­fi­cile pro­gram SER-109 af­ter a crush­ing Phase II fail. Ege held a va­ri­ety of posts at Mer­ck since 2003, ex­it­ing as the glob­al lead for dig­i­tal strat­e­gy in the phar­ma gi­ant’s man­u­fac­tur­ing di­vi­sion. A J&J and Gen­zyme vet, Gansler leaps to Seres from Ari­ad Phar­ma­ceu­ti­cals, where she was SVP, head of hu­man re­sources.

Behrad De­r­akhshan

Michael Car­ruthers and Behrad De­r­akhshan have head­ed to mus­cu­loskele­tal dis­ease-fo­cused Edge­wise Ther­a­peu­tics as CFO and CBO, re­spec­tive­ly, three months af­ter the Boul­der, CO biotech made an­oth­er C-suite move by bring­ing in CMO Kirsten Gruis. Edge­wise’s lead can­di­date, EDG-5506 for Duchenne and Beck­er mus­cu­lar dy­s­tro­phy, is in clin­i­cal de­vel­op­ment. Car­ruthers was CFO at 2 oth­er Boul­der com­pa­nies, Ar­ray Bio­Phar­ma and Ni­valis Ther­a­peu­tics, where he was al­so in­ter­im pres­i­dent. De­r­akhshan, an Alex­ion vet, was most re­cent­ly CBO at Vec­tivBio and led busi­ness de­vel­op­ment at Ther­a­chon from 2017-19.

→ Fo­cused on sep­sis-as­so­ci­at­ed acute kid­ney in­jury and in the midst of a Phase III piv­otal clin­i­cal tri­al, Dutch biotech AM-Phar­ma has wel­comed Maarten Kraan as CMO and Te­un van de Laar as VP, man­u­fac­tur­ing and sup­ply chain man­age­ment. Kraan has been around the R&D block with Bris­tol My­ers Squibb, Roche and As­traZeneca, pri­mar­i­ly in in­flam­ma­to­ry dis­eases, and most re­cent­ly led R&D at French phar­ma Pierre Fab­re Phar­ma­ceu­ti­cals. A 10-year vet of Mer­ck, van de Laar moves on to AM-Phar­ma from his post at Aduro Biotech as VP, CMC tech­ni­cal op­er­a­tions.

George El­dridge

Co-found­ed by Bob Langer and fo­cused on oral sus­tained-re­lease ther­a­pies, Wa­ter­town, MA-based Lyn­dra Ther­a­peu­tics has named George El­dridge as their CFO. El­dridge has been a CFO at a bushel of biotechs in the past, in­clud­ing Pro­teon Ther­a­peu­tics (his pre­vi­ous gig), Tar­gan­ta Ther­a­peu­tics and The­ri­on Bi­o­log­ics. This marks the third se­nior man­age­ment po­si­tion to be filled at Lyn­dra since Feb­ru­ary, with El­dridge join­ing chief tech­nol­o­gy of­fi­cer Örn Al­mars­son and CMO Richard Scran­ton.

→ Char­lottesville, VA-based Dif­fu­sion Phar­ma­ceu­ti­cals, look­ing to treat dis­eases where hy­pox­ia plays a big role, has re­cruit­ed Chris Gal­loway as CMO. A for­mer med­ical af­fairs di­rec­tor in Mer­ck’s im­munother­a­py di­vi­sion, Gal­loway has spent the last 2 years as se­nior med­ical di­rec­tor in crit­i­cal care for San Diego biotech La Jol­la Phar­ma­ceu­ti­cal.

David Ja­cobs

→ Swiss top­i­cal eye drug de­vel­op­er Oculis SA has brought on David Ja­cobs as chief de­vel­op­ment of­fi­cer of its US of­fice, where Sylvia Che­ung was ap­point­ed CFO last month. Ja­cobs had been VP, clin­i­cal de­vel­op­ment and med­ical af­fairs at Os­mot­i­ca Phar­ma­ceu­ti­cals for the last 3 years and held drug de­vel­op­ment roles at J&J, Dai­ichi Sankyo, Ap­tal­is Phar­ma­ceu­ti­cals and King Phar­ma­ceu­ti­cals.

Mereo Bio­Phar­ma has made a cou­ple of new per­son­nel moves with Chris­tine Fox as CFO and Hei­di Pe­tersen as SVP, reg­u­la­to­ry af­fairs. Start­ing in Jan­u­ary 2021, Fox will re­place in­ter­im CFO Michael Wyz­ga, who will stay on as a board mem­ber. A KP­MG vet, Fox had been group fi­nan­cial con­troller and trea­sur­er for Trav­el­port. Pe­tersen, who starts Nov. 2, has been in reg­u­la­to­ry af­fairs for 25 years and jumps over to Mereo from Kar­tos Ther­a­peu­tics. She’s al­so been a reg­u­la­to­ry ex­ec at Phar­ma­cylics and Im­mune De­sign, which was scooped up by Mer­ck in March 2019.

→ Af­ter rak­ing in $28.5 mil­lion to dive in­to Phase II ear­li­er this month, Sen­sei Bio­ther­a­peu­tics has named Anu Hoey as CBO. Hoey joins the com­pa­ny af­ter hav­ing served in roles at Sec­ond Genome, In­ven­ra, Ar­cus Bio­sciences and Sutro Bio­phar­ma.

→ While de­vel­op­ing the first blood-based test of ear­ly on­set Alzheimer’s dis­ease, Di­a­dem has plucked up Paul Kin­non as CEO. Paul jumps to the helm with stints at Pre­dic­tIm­mune, Transge­nom­ic, ZyGem and Life Tech­nolo­gies (now Ther­mo Fish­er) among oth­ers un­der his belt.

Sam Whit­ing

Sam Whit­ing has breezed in­to Ver­sant-backed South San Fran­cis­co on­col­o­gy play­er Tem­pest Ther­a­peu­tics, which is de­vel­op­ing their small mol­e­cule pipeline to treat tu­mors, as EVP and CMO. Whit­ing, who was in clin­i­cal re­search ear­ly in his ca­reer at Fred Hutch, was with Calithera since 2016 and had been their SVP of clin­i­cal de­vel­op­ment pri­or to his ar­rival at Tem­pest.

→ Speak­ing of Ver­sant-backed biotechs, neu­rore­gen­er­a­tion start­up Pipeline Ther­a­peu­tics has hand­ed the CFO reins to Pe­ter Slover. He’s an alum of 2 oth­er biotechs in the San Diego area — at Sophiris Bio, where he was their CFO since 2013, and be­fore that at Anadys Phar­ma­ceu­ti­cals, where he was VP, fi­nance and op­er­a­tions among sev­er­al man­age­ment roles dur­ing his 8 years.

Erin Cowhig

Erin Cowhig has been named as the first chief peo­ple of­fi­cer of Cam­bridge, MA drug dis­cov­ery pi­o­neer Nim­bus Ther­a­peu­tics, which chose 4 new tar­gets for its pipeline in June. Cowhig has left Ver­tex, where she had 2 sep­a­rate tenures in hu­man re­sources. Sand­wiched in be­tween, Cowhig was se­nior di­rec­tor, tal­ent ac­qui­si­tion and tal­ent man­age­ment at Agios.

→ Ef­fec­tive last Fri­day, Jen­nifer Chien has stepped aside as chief com­mer­cial of­fi­cer of Pitts­burgh-based Krys­tal Biotech “to pur­sue an­oth­er op­por­tu­ni­ty.” A group of mem­bers from the com­mer­cial team will fill in while the search gets un­der­way for her re­place­ment. Chien is a Sanofi alum who joined Krys­tal in Jan­u­ary.

Moya Daniels

→ San Diego re­gen­er­a­tive med­i­cine de­vel­op­er His­to­gen has se­lect­ed Moya Daniels as EVP and head of reg­u­la­to­ry, qual­i­ty and clin­i­cal op­er­a­tions. Daniels makes the move af­ter be­ing SVP of GMP qual­i­ty at San­Bio. She’s al­so held po­si­tions in reg­u­la­to­ry af­fairs and qual­i­ty as­sur­ance at Or­chard Ther­a­peu­tics, Fate Ther­a­peu­tics and Osiris Ther­a­peu­tics.

David Crist has been ap­point­ed VP of sales at Boston-based Aveo On­col­o­gy, whose NDA sub­mis­sion for tivozanib — a vas­cu­lar en­dothe­lial growth fac­tor re­cep­tor ty­ro­sine ki­nase in­hibitor (VEG­FR-TKI) to treat re­lapsed or re­frac­to­ry re­nal cell car­ci­no­ma — was ac­cept­ed for fil­ing in June af­ter re­peat­ed re­buffs and is now un­der re­view with an ac­tion date of March 31, 2021. Pri­or to Aveo, Crist was gen­er­al man­ag­er of hema­tol­ogy on­col­o­gy US fran­chise at ar­genx.

Hol­ly Vance

→ Seat­tle-based Ne­oleukin Ther­a­peu­tics, whose lead can­di­date NL-201 is a de no­vo IL-2/IL-15 ag­o­nist for can­cer, has named Hol­ly Vance their gen­er­al coun­sel. Vance was pre­vi­ous­ly as­so­ciate gen­er­al coun­sel for the Bill and Melin­da Gates Foun­da­tion, lend­ing guid­ance to the foun­da­tion’s Strate­gic In­vest­ment Fund.

Phar­maEssen­tia has tapped Ray­mond Ur­ban­s­ki as head of clin­i­cal de­vel­op­ment and med­ical af­fairs for its US sub­sidiary. Ur­ban­s­ki hops aboard af­ter stints at GT Bio­phar­ma — as CMO and pres­i­dent — Mannkind and My­lan.

Matthew Pat­ter­son is lend­ing a hand on the board of di­rec­tors to both PureTech Health — which late last month was gun­ning for a Nas­daq de­but — and on­col­o­gy play­er Vor Bio­phar­ma. Pat­ter­son is strate­gic ad­vi­sor to Au­dentes, the com­pa­ny he co-found­ed and helmed un­til the Astel­las ac­qui­si­tion closed in Jan­u­ary.

Mark Cor­ri­g­an

→ Af­ter bring­ing in Bud Brigham as a board mem­ber last month, Austin im­muno-on­col­o­gy com­pa­ny Perseus Hold­ings has giv­en Mark Cor­ri­g­an a seat at the board of di­rec­tors. Cor­ri­g­an was re­cent­ly CEO of Cor­re­vio and pres­i­dent of R&D at Tremeau Phar­ma­ceu­ti­cals.

→ Dig­i­tal health com­pa­ny Ar­i­ana Phar­ma has brought on Kia Mote­sharei to its board of di­rec­tors. Cur­rent­ly, Morte­sharei serves as SVP of busi­ness de­vel­op­ment & cor­po­rate strat­e­gy with Akcea Ther­a­peu­tics. In the past, he held roles at Mer­ck KGaA, Dyax, Gen­fit and Ac­tivX.

→ De­vel­op­ing ther­a­pies to re­pair dam­aged tis­sues, Pitts­burgh-based Noveome Ther­a­peu­tics has cho­sen Michelle Berrey and An­na­maria Kausz to be on the board of di­rec­tors. Berrey, the ex-CEO of Chimerix, is now a sci­en­tif­ic ad­vi­sor for Vi­iV/GSK. Kausz has been CMO at Al­lena Phar­ma­ceu­ti­cals since 2015.

Gi­na Con­syl­man

John McHutchi­son-led As­sem­bly Bio­sciences, which part­nered on its hep B drugs with BeiGene in Ju­ly, has made Gi­na Con­syl­man a mem­ber of their board of di­rec­tors. A Bio­gen and Ve­rastem vet, Con­syl­man is Iron­wood Phar­ma­ceu­ti­cals’ SVP and CFO.

Gilead-part­nered Vi­en­na-based im­munother­a­py com­pa­ny Hookipa has made the ad­di­tion of Jean-Charles So­ria to its board of di­rec­tors. So­ria is a pro­fes­sor of med­i­cine and med­ical on­col­o­gy at the Uni­ver­si­ty of Paris-Saclay and cur­rent­ly serves as di­rec­tor gen­er­al of the Gus­tave Roussy Can­cer Cen­ter.

Gre­go­ry Berk has been added to the board of di­rec­tors at can­cer-fo­cused In­flec­tion Bio­sciences out of Dublin. Berk is a long­time CMO at such biotechs as Vedantra Phar­ma­ceu­ti­cals, Ve­rastem and Sideris Phar­ma­ceu­ti­cals.

Tanya Lewis

→ On­colyt­ic im­munother­a­py de­vel­op­er Replimune out of Woburn, MA, has ap­point­ed Tanya Lewis to the board of di­rec­tors. Lewis, a long­time reg­u­la­to­ry ex­ec, is Karyopharm’s EVP, chief reg­u­la­to­ry strat­e­gy and strate­gic op­er­a­tions.

Bi­cy­cle Ther­a­peu­tics has in­creased the mem­ber­ship in their sci­en­tif­ic ad­vi­so­ry board. It now in­cludes Uni­ver­si­ty of Penn­syl­va­nia pro­fes­sor Gar­ret FitzGer­ald, Ar­se­nal­Bio CSO Jane Gro­gan, Can­cer Re­search UK chief clin­i­cian Charles Swan­ton and Cae­tano Reis e Sousa of the Crick In­sti­tute.

Albert Bourla (Photo by Steven Ferdman/Getty Images)

UP­DAT­ED: Pfiz­er fields a CRL for a $295M rare dis­ease play, giv­ing ri­val a big head start

Pfizer won’t be adding a new rare disease drug to the franchise club — for now, anyway.

The pharma giant put out word that their FDA application for the growth hormone therapy somatrogon got the regulatory heave-ho, though they didn’t even hint at a reason for the CRL. Following standard operating procedure, Pfizer said in a terse missive that they would be working with regulators on a followup.

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Graphic: Alexander Lefterov for Endpoints News

Small biotechs with big drug am­bi­tions threat­en to up­end the tra­di­tion­al drug launch play­book

Of the countless decisions Vlad Coric had to make as Biohaven’s CEO over the past seven years, there was one that felt particularly nerve-wracking: Instead of selling to a Big Pharma, the company decided it would commercialize its migraine drug itself.

“I remember some investors yelling and pounding on the table like, you can’t do this. What are you thinking? You’re going to get crushed by AbbVie,” he recalled.

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Mar­ket­ingRx roundup: Pfiz­er de­buts Pre­vnar 20 TV ads; Lil­ly gets first FDA 2022 pro­mo slap down let­ter

Pfizer debuted its first TV ad for its Prevnar 20 next-generation pneumococcal pneumonia vaccine. In the 60-second spot, several people (actor portrayals) with their ages listed as 65 or older are shown walking into a clinic as they turn to say they’re getting vaccinated with Prevnar 20 because they’re at risk.

The update to Pfizer’s blockbuster Prevnar 13 vaccine was approved in June, and as its name suggests is a vaccine for 20 serotypes — the original 13 plus seven more that cause pneumococcal disease. Pfizer used to spend heavily on TV ads to promote Prevnar 13 in 2018 and 2019 but cut back its TV budgets in the past two fall and winter seasonal spending cycles. Prevnar had been Pfizer’s top-selling drug, notching sales of just under $6 billion in 2020, and was the world’s top-selling vaccine before the Covid-19 vaccines came to market last year.

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A new can­cer im­munother­a­py brings cau­tious hope for a field long await­ing the next big break­through

Bob Seibert sat silent across from his daughter at their favorite Spanish restaurant near his home in Charleston County, SC, their paella growing cold as he read through all the places in his body doctors found tumors.

He had texted his wife, a pediatric intensive care nurse, when he got the alert that his online chart was ready. Although he saw immediately it was bad, many of the terms — peritoneal, right iliac — were inscrutable. But she was five hours downstate, at a loud group dinner the night before another daughter’s cheer competition.

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Roy Baynes, Merck

FDA bats back Mer­ck’s ‘pipeline in a prod­uct,’ de­mands more ef­fi­ca­cy da­ta

Despite some heavy blowback from analysts, Merck execs maintained an upbeat attitude about the market potential of its chronic cough drug gefapixant. But the confidence may be fading somewhat today as Merck puts out news that the FDA is handing back its application with a CRL.

Dubbed by Merck’s development chief Roy Baynes as a “pipeline in a product” with a variety of potential uses, Merck had fielded positive late-stage data demonstrating the drug’s ability to combat chronic cough. The drug dramatically reduced chronic cough in Phase III, but so did placebo, leaving Merck’s research team with a marginal success on the p-value side of the equation.

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Florida Gov. Ron DeSantis (AP Photo/Wilfredo Lee, File)

Opin­ion: Flori­da is so mAb crazy, Ron De­San­tis wants to use mAbs that don't work

Florida Gov. Ron DeSantis is trying so hard to politicize the FDA and demonize the federal government that he entered into an alternate universe on Monday evening in describing a recent FDA action to restrict the use of two monoclonal antibody, or mAb, treatments for Covid-19 that don’t work against Omicron.

Without further ado, let’s break down his statement from last night, line by line, adjective by adjective.

Not cheap­er by the dozen: Bris­tol My­ers be­comes the 12th phar­ma com­pa­ny to re­strict 340B sales

Bristol Myers Squibb recently joined 11 of its peer pharma companies in limiting how many contract pharmacies can access certain drugs discounted by a federal program known as 340B.

Bristol Myers is just the latest in a series of high-profile pharma companies moving in their own direction as the Biden administration’s Health Resources and Services Administration struggles to rein in the drug discount program for the neediest Americans.

Joaquin Duato, J&J CEO (Photo by Charles Sykes/Invision/AP)

New J&J CEO Joaquin Du­a­to promis­es an ag­gres­sive M&A hunt in quest to grow phar­ma sales

Joaquin Duato stepped away from the sideline and directly into the spotlight on Tuesday, delivering his first quarterly review for J&J as its newly-tapped CEO after an 11-year run in senior posts. And he had some mixed financial news to deliver today while laying claim to a string of blockbuster drugs in the making and outlining an appetite for small and medium-sized M&A deals.

Duato also didn’t exactly shun large buyouts when asked about the future of the company’s medtech business — where they look to be in either the top or number 2 position in every segment they’re in — even though the bar for getting those deals done is so much higher.

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Amgen's Twitter campaign #DearAsthma inspired thousands of people to express struggles and frustrations with the disease

Am­gen’s #Dear­Asth­ma spon­sored tweet lands big on game day, spark­ing thou­sands to re­spond

Amgen wanted to know how people with asthma really felt about daily life with the disease. So it bought a promoted tweet on Twitter noting the not-so-simple realities of life with asthma and ended the post with a #DearAsthma hashtag, a megaphone emoji and a re-tweet button.

That was just over one week ago and the responses haven’t stopped. More than 7,000 posts so far on Twitter replied to #DearAsthma to detail struggles of daily life, expressing humor, frustration and sometimes anger. More than a few f-bombs have been typed or gif-ed in reply to communicate just how much many people “hate” the disease.