Astel­las shells out $35M up­front to Cull­gen in pro­tein de­grad­er de­vel­op­ment deal

Astel­las is ex­pand­ing its mark in the grow­ing pro­tein degra­da­tion space with a po­ten­tial $1.9 bil­lion deal with San Diego and Shang­hai-based Cull­gen.

Cull­gen, which closed a $50 mil­lion Se­ries B round in 2021 to de­vel­op its pro­tein degra­da­tion plat­form and pipeline, will get an up­front pay­ment of $35 mil­lion from the phar­ma gi­ant. An ad­di­tion­al $85 mil­lion is at stake if Astel­las us­es a li­cense op­tion for the al­ready-iden­ti­fied lead pro­gram: a cell cy­cle pro­tein de­grad­er for the treat­ment of breast can­cer and oth­er sol­id tu­mors.

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