As­traZeneca sells off heart fail­ure and hy­per­ten­sion drugs to Chep­lapharm for $400M

Out with the old and in with the new: As­traZeneca is sell­ing off two heart fail­ure and hy­per­ten­sion drugs to Ger­many-based Chep­lapharm, bag­ging $400 mil­lion and mak­ing way for de­vel­op­ment in oth­er ar­eas.

Chep­lapharm paid $200 mil­lion for the Eu­ro­pean rights to At­a­cand (can­desar­tan cilex­etil) and At­a­cand Plus (can­desar­tan cilex­etil and hy­drochloroth­iazide) back in 2018. They’re now dou­bling that amount for com­mer­cial con­trol in more than 70 coun­tries.

Pas­cal So­ri­ot As­traZeneca

Mean­while, As­traZeneca said the sale will al­low them to fo­cus on three main ther­a­py ar­eas: on­col­o­gy, car­dio­vas­cu­lar, re­nal and me­tab­o­lism, and res­pi­ra­to­ry and im­munol­o­gy. Last year, As­traZeneca swept away the brand name Med­Im­mune and brought in José Basel­ga to run can­cer R&D op­er­a­tions in a ma­jor re­struc­tur­ing. On­col­o­gy has been a main fo­cus as CEO Pas­cal So­ri­ot builds out the com­pa­ny’s port­fo­lio.

Not to men­tion, the phar­ma is one of the lead­ers in the race for a Covid-19 vac­cine. Ear­li­er this month, the EMA grant­ed a rolling re­view for its can­di­date in de­vel­op­ment with Ox­ford Uni­ver­si­ty.

“This agree­ment forms part of our strat­e­gy to care­ful­ly man­age the ma­ture med­i­cines, en­abling rein­vest­ment in our main ther­a­py ar­eas to bring in­no­v­a­tive new med­i­cines to pa­tients,” Ru­ud Dob­ber, EVP of As­traZeneca’s bio­phar­ma­ceu­ti­cals busi­ness unit, said in a state­ment.

As­traZeneca will man­u­fac­ture and sell At­a­cand for the next three years as the com­pa­nies tran­si­tion. The drug, de­vel­oped with Take­da, was first ap­proved in 1998, and is now in­di­cat­ed to treat hy­per­ten­sion in adults and chil­dren, and heart fail­ure in adults. At­a­cand Plus is ap­proved for the treat­ment of hy­per­ten­sion when can­desar­tan or hy­drochloroth­iazide monother­a­py is “not suf­fi­cient­ly ef­fec­tive,” ac­cord­ing to the com­pa­ny.

Last year, At­a­cand earned $221 mil­lion in glob­al sales, ac­cord­ing to As­traZeneca’s Q4 re­sults. Chep­lapharm agreed to pay $250 mil­lion once the deal clos­es, and the rest in the first half of 2021. As­traZeneca said the sale will “not im­pact the com­pa­ny’s fi­nan­cial guid­ance for 2020.”

Im­ple­ment­ing re­silience in the clin­i­cal tri­al sup­ply chain

Since January 2020, the clinical trials ecosystem has quickly evolved to manage roadblocks impeding clinical trial integrity, and patient care and safety amid a global pandemic. Closed borders, reduced air traffic and delayed or canceled flights disrupted global distribution, revealing how flexible logistics and supply chains can secure the timely delivery of clinical drug products and therapies to sites and patients.

In fi­nal days at Mer­ck, Roger Perl­mut­ter bets big on a lit­tle-known Covid-19 treat­ment

Roger Perlmutter is spending his last days at Merck, well, spending.

Two weeks after snapping up the antibody-drug conjugate biotech VelosBio for $2.75 billion, Merck announced today that it had purchased OncoImmune and its experimental Covid-19 drug for $425 million. The drug, known as CD24Fc, appeared to reduce the risk of respiratory failure or death in severe Covid-19 patients by 50% in a 203-person Phase III trial, OncoImmune said in September.

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Pascal Soriot (AP Images)

UP­DAT­ED: As­traZeneca, Ox­ford on the de­fen­sive as skep­tics dis­miss 70% av­er­age ef­fi­ca­cy for Covid-19 vac­cine

On the third straight Monday that the world wakes up to positive vaccine news, AstraZeneca and Oxford are declaring a new Phase III milestone in the fight against the pandemic. Not everyone is convinced they will play a big part, though.

With an average efficacy of 70%, the headline number struck analysts as less impressive than the 95% and 94.5% protection that Pfizer/BioNTech and Moderna have boasted in the past two weeks, respectively. But the British partners say they have several other bright spots going for their candidate. One of the two dosing regimens tested in Phase III showed a better profile, bringing efficacy up to 90%; the adenovirus vector-based vaccine requires minimal refrigeration, which may mean easier distribution; and AstraZeneca has pledged to sell it at a fraction of the price that the other two vaccine developers are charging.

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John Maraganore, Alnylam CEO (Scott Eisen/Bloomberg via Getty Images)

Al­ny­lam gets the green light from the FDA for drug #3 — and CEO John Maraganore is ready to roll

Score another early win at the FDA for Alnylam.

The FDA put out word today that the agency has approved its third drug, lumasiran, for primary hyperoxaluria type 1, better known as PH1. The news comes just 4 days after the European Commission took the lead in offering a green light.

An ultra rare genetic condition, Alnylam CEO John Maraganore says there are only some 1,000 to 1,700 patients in the US and Europe at any particular point. The patients, mostly kids, suffer from an overproduction of oxalate in the liver that spurs the development of kidney stones, right through to end stage kidney disease.

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Bob Nelsen (Photo by Michael Kovac/Getty Images)

Bob Nelsen rais­es $800M and re­cruits a star-stud­ded board to build the 'Fox­con­n' of biotech

Bob Nelsen spent his pandemic spring in his Seattle home, talking on the phone with Luciana Borio, the scientist who used to run pandemic preparedness on the National Security Council, and fuming with her about the dire state of American manufacturing.

Companies were rushing to develop vaccines and antibodies for the new virus, but even if they succeeded, there was no immediate supply chain or infrastructure to mass-produce them in a way that could make a dent in the outbreak.

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Ramy Farid, Schrödinger CEO (Schrödinger)

Bris­tol My­ers fronts new Schrödinger al­liance with $55M up­front, ex­pand­ing pre­ci­sion on­col­o­gy pro­file

Bristol Myers Squibb has a new R&D partner, one to which they’re paying a pretty penny to use their discovery platform.

The pharma company is doling out $55 million upfront to Schrödinger $SDGR to work on up to five small molecules, with the potential for $2.7 billion in milestone payments. Schrödinger’s initial targets include HIF-2 alpha and SOS1/KRAS for a type of kidney cancer and KRAS-driven cancers, respectively.

Carl Hansen, AbCellera CEO (University of British Columbia)

From a pair of Air Jor­dans to a $200M-plus IPO, Carl Hansen is craft­ing an overnight R&D for­tune fu­eled by Covid-19

Back in the summer of 2019, Carl Hansen left his post as a professor at the University of British Columbia to go full time as the CEO at a low-profile antibody shop he had founded called AbCellera.

As biotech CEOs go, even after a fundraise Hansen wasn’t paid a whole heck of a lot. He ended up earning right at $250,000 for the year. His compensation package included a loan — which he later paid back — and a pair of Air Jordan tennis shoes. His newly-hired CFO, Andrew Booth, got a sweeter pay packet than that — which included his own pair of Air Jordans.

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Leonard Schleifer, Regeneron CEO (Andrew Harnik/AP)

Trail­ing Eli Lil­ly by 12 days, Re­gen­eron gets the FDA OK for their Covid-19 an­ti­body cock­tail

A month and a half after becoming the experimental treatment of choice for a newly diagnosed president, Regeneron’s antibody cocktail has received emergency use authorization from the FDA. It will be used to treat non-hospitalized Covid-19 patients who are at high-risk of progressing.

Although the Rgeneron drug is not the first antibody treatment authorized by the FDA, the news comes as a significant milestone for a company and a treatment scientists have watched closely since the outbreak began.

Bahija Jallal (file photo)

TCR pi­o­neer Im­muno­core scores a first with a land­mark PhI­II snap­shot on over­all sur­vival for a rare melanoma

Bahija Jallal’s crew at TCR pioneer Immunocore says they have nailed down a promising set of pivotal data for their lead drug in a frontline setting for a solid tumor. And they are framing this early interim readout as the convincing snapshot they need to prove that their platform can deliver on a string of breakthrough therapies now in the clinic or planned for it.

In advance of the Monday announcement, Jallal and R&D chief David Berman took some time to walk me through the first round of Phase III data for their lead TCR designed to treat rare, frontline cases of metastatic uveal melanoma that come with a grim set of survival expectations.

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