Hongkui Deng (Nature)

Ax­olotls, chem­i­cal cock­tails, and a new route for stem cell ther­a­py — maybe

Ax­olotls are way ahead of stem cell sci­en­tists. When the frilly, smil­ing sala­man­ders na­tive to Mex­i­co City lose a limb, they turn back the clock on their adult cells, ‘re­pro­gram­ming’ them back in­to stem cells, and ul­ti­mate­ly, re­grow their en­tire limb.

In some cas­es, ax­olotls have re­gen­er­at­ed parts of their brains, their spines, and even their hearts.

Ear­li­er this month, a group of Chi­nese sci­en­tists led by Hongkui Deng re­port­ed in Na­ture that they were able to use on­ly chem­i­cal com­pounds to re­pro­gram hu­man cells in­to stem cells. The fun part? The chem­i­cal­ly in­duced cells shared sim­i­lar prop­er­ties with ax­olotl limb re­gen­er­a­tion cells.

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