Bay Area start­up Cor­texyme gains a $76M round to back a PhII Alzheimer's study, with a new tar­get in their sights

With the ev­i­dence in­creas­ing­ly weigh­ing in against amy­loid be­ta as the best so­lo tar­get for Alzheimer’s, a start­up out of San Fran­cis­co has iden­ti­fied a brand new tar­get and now has a $76 mil­lion B round to put it through its first proof-of-con­cept study.

The sci­en­tif­ic in­spi­ra­tion for the biotech comes from UCSF psy­chi­a­trist Steve Dominy, who iden­ti­fied a bac­te­r­i­al pathogen that he be­lieves plays a key role in the pathol­o­gy of the dis­ease. Ini­tial­ly work­ing out of JLABS Bay Area fa­cil­i­ty, Cor­texyme has now com­plet­ed an­i­mal stud­ies as well as a Phase I safe­ty test to set the stage for a Phase II hu­man study.

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