BeiGene bags a stag­ger­ing $903M IPO on the HKEX — and still man­ages to spark some ner­vous fret­ting

BeiGene’s sec­ondary IPO on the Hong Kong ex­change says a lot about the sky-high ex­pec­ta­tions of the biotechs lin­ing up to cash in there un­der more lib­er­al list­ing rules.

The biotech raised $903 mil­lion, and that was on the low end of the range.

HKEX is com­mand­ing at­ten­tion from bio­phar­ma for a sec­ond day with the news that BeiGene’s IPO fell shy of the $1 bil­lion ceil­ing it was reach­ing for.

BeiGene’s sec­ondary IPO, as re­port­ed by Reuters, comes as biotechs join the queue for a bo­nan­za of wind­fall rais­es in Hong Kong. The first of them, As­cle­tis Phar­ma, be­gan trad­ing Wednes­day af­ter pock­et­ing $400 mil­lion and closed flat.

By every ac­count, BeiGene’s haul to­day is stag­ger­ing. BeiGene’s 2016 Nas­daq de­but $BGNE brought home $158 mil­lion, and the largest biotech IPO on Nas­daq so far this year went to Ru­bius at $241 mil­lion.

The list­ing price, though, does rep­re­sent a dis­count of 1.6% against its clos­ing price in the US on Wednes­day. Quot­ing bro­kers, South Chi­na Morn­ing Post ex­plained that Chi­na’s re­cent fake vac­cine scan­dal, adding to poor mar­ket sen­ti­ment in gen­er­al, is to blame for the luke­warm re­tail re­sponse that caused the “huge set­back.”

“The re­tail in­vestors are more short-term mar­ket dri­ven,” Joseph Tong of Mor­ton Se­cu­ri­ties told the SCMP. “The in­sti­tu­tion­al side will be longer term and judge it on com­pa­ny fun­da­men­tal val­ues.”

Pri­or to the pub­lic launch, Bei­jing-based BeiGene se­cured four cor­ner­stone in­vestors on both sides of the Pa­cif­ic to buy 19.8 mil­lion shares out of the 65.5 mil­lion new shares, or 8.55% of its en­larged share cap­i­tal, it was sell­ing. They in­clude New York-based hedge fund Bak­er Bros Ad­vi­sors, Sin­ga­pore’s sov­er­eign wealth fund GIC, and two of Chi­na’s most in­flu­en­tial biotech VCs, Hill­house Cap­i­tal Man­age­ment and Al­ly Bridge.

Aside from the price and the list of mar­quee cor­ner­stone back­ers, BeiGene’s IPO jour­ney was al­so re­mark­able for its speed. While it was un­clear when BeiGene first sub­mit­ted its ap­pli­ca­tion for the dual list­ing — word on the street was around mid-June — its meet­ing with the HKEX list­ing com­mit­tee took place less than two weeks ago. Its stock is slat­ed to go live on Au­gust 8.

That will cer­tain­ly mark an­oth­er mile­stone for HKEX as it con­tin­ues to brand it­self as the ide­al des­ti­na­tion for Chi­nese biotech IPOs. Af­ter­all, the im­mense suc­cess that BeiGene had en­joyed on Nas­daq was long seen as an im­pe­tus for Hong Kong to change its rules in the first place.

In its fil­ing, BeiGene wrote that it be­lieves it’s “well po­si­tioned to cap­ture the sig­nif­i­cant mar­ket op­por­tu­ni­ties in Chi­na” with its im­muno-on­col­o­gy drugs zanubru­ti­nib, tislelizum­ab and pami­parib, all of which would ben­e­fit from the raise, from clin­i­cal tri­als to reg­is­tra­tion and com­mer­cial­iza­tion in both Chi­na and the US.

Mer­ck is tak­ing the ax to its US op­er­a­tions, cut­ting 500 jobs in its lat­est re­or­ga­ni­za­tion

Merck is cutting 500 jobs in its US sales and headquarters commercial teams in its latest effort to find new ways to streamline the operation.

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Alice Shaw, Lung Cancer Foundation of America

Top ALK ex­pert and can­cer drug re­searcher Al­ice Shaw bids adieu to acad­e­mia, hel­lo to No­var­tis

Jay Bradner has recruited a marquee oncology drug researcher into the ranks of the Novartis Institutes for BioMedical Research. Alice Shaw is jumping from prestigious posts intertwined through Mass General, Harvard and Dana-Farber to take the lead of NIBR’s translational clinical oncology group.

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Hal Barron, GSK's president of R&D and CSO, speaks to Endpoints News founder and editor John Carroll in London at Endpoints' #UKBIO19 summit on October 8, 2019

[Video] Cel­e­brat­ing tri­al fail­ures, chang­ing the cul­ture and al­ly­ing with Cal­i­for­nia dream­ers: R&D chief Hal Bar­ron talks about a new era at GSK

Last week I had a chance to sit down with Hal Barron at Endpoints’ #UKBIO19 summit to discuss his views on R&D at GSK, a topic that has been central to his life since he took the top research post close to 2 years ago. During the conversation, Barron talked about changing the culture at GSK, a move that involves several new approaches — one of which involves celebrating their setbacks as they shift resources to the most promising programs in the pipeline. Barron also discussed his new alliances in the Bay Area — including his collaboration pact with Lyell, which we covered here — frankly assesses the pluses and minuses of the UK drug development scene, and talks about his plans for making GSK a much more effective drug developer.

This is one discussion you won’t want to miss. Insider and Enterprise subscribers can log-in to watch the video.

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Med­ical an­i­ma­tion: Mak­ing it eas­i­er for the site and the pa­tient to un­der­stand

Medical animation has in recent years become an increasingly important tool for conveying niche information to a varied audience, particularly to those audiences without expertise in the specialist area. Science programmes today, for example, have moved from the piece-to-camera of the university professor explaining how a complex disease mechanism works, to actually showing the viewer first-hand what it might look like to shrink ourselves down to the size of an ant’s foot, and travel inside the human body to witness these processes in action. Effectively communicating a complex disease pathophysiology, or the novel mechanism of action of a new drug, can be complex. This is especially difficult when the audience domain knowledge is limited or non-existent. Medical animation can help with this communication challenge in several ways.
Improved accessibility to visualisation
Visualisation is a core component of our ability to understand a concept. Ask 10 people to visualise an apple, and each will come up with a slightly different image, some apples smaller than others, some more round, some with bites taken. Acceptable, you say, we can move on to the next part of the story. Now ask 10 people to visualise how HIV’s capsid protein gets arranged into the hexamers and pentamers that form the viral capsid that holds HIV’s genetic material. This request may pose a challenge even to someone with some virology knowledge, and it is that inability to effectively visualise what is going on that holds us back from fully understanding the rest of the story. So how does medical animation help us to overcome this visualisation challenge?

Flu Virus (Source: CDC)

FDA ex­pands Xofluza ap­proval as Roche strug­gles to catch loom­ing flu mar­ket

As a potentially powerful flu season looms, so does a big test for Roche and its new flu drug, Xofluza. The Swiss giant just got a small boost in advance of that test as the FDA expanded Xofluza’s indication to include patients at high risk of developing flu-related complications.

Xofluza (baloxavir marboxil) was approved last October in the US, the first landmark flu drug approval in 20 years and a much-needed green light for a company that had watched its leading flu drug Tamiflu get eaten alive by generics. Like its predecessor, the pill offered a reduction in flu symptoms but not a cure.

EMA backs sev­en ther­a­pies, in­clud­ing Mer­ck­'s Ebo­la vac­cine

The first-ever Ebola vaccine is on the precipice of approval after the European Medicine’s Agency (EMA) backed the Merck product in this week’s roster of recommendations.

The drugmaker $MRK began developing the vaccine, christened Ervebo, during the West African outbreak that occurred between 2014 and 2016, killing more than 11,000.

The current outbreak in the Democratic Republic of Congo (DRC) has shown case fatality rates of approximately 67%, the agency estimated. Earlier this year, the WHO declared the outbreak — which so far has infected more than 3,000 people — a public health emergency of international concern.

Ronald Herb­st fol­lows Med­Im­mune ex­o­dus to Pyx­is CSO post; Jeff God­dard to suc­ceed CEO of AIT Bio­science

→ The outflow of top execs from MedImmune continues to fill the leadership ranks of smaller biotechs. The latest to take off is Ronald Herbst, the head of oncology research, who’s assuming the CSO post at Pyxis Oncology.  

Herbst was part of the old MedImmune organization AstraZeneca CEO Pascal Soriot restructured earlier this year, reorganizing the company and eliminating the storied subsidiary as a separate organization.

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UP­DAT­ED: J&J's Xarel­to, Amar­in's Vas­cepa are cost-ef­fec­tive, not bud­get friend­ly — ICER

ICER, an increasingly influential cost-effectiveness watchdog in the United States, has concluded in its review of treatments for cardiovascular disease that while the cost of J&J’s Xarelto and Amarin’s Vascepa meet its benchmark for value pricing — the two treatments will not likely treat as many patients as hoped without surpassing the annual budget threshold calculated by ICER for each therapy.

Mi­rati preps its first look at their KRAS G12C con­tender, and they have to clear a high bar for suc­cess

If you’re a big KRAS G12C fan, mark your calendars for October 28 at 4:20 pm EDT.

That’s when Mirati $MRTX will unveil its first peek at the early clinical data available on MRTX849 in presentations at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics in Boston.

Mirati has been experiencing the full effect of a rival’s initial success at targeting the G12C pocket found on KRAS, offering the biotech some support on the concept they’re after — and biotech fans a race to the top. Amgen made a big splash with its first positive snapshot on lung cancer, but deflated sky-high expectations as it proved harder to find similar benefits in other types of cancers.

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