Bellicum halts trials after serious adverse event, looks for 'strategic alternatives'
Bellicum Pharmaceuticals is halting the Phase I/II trials for the only two candidates in its pipeline after reporting a serious adverse event — and is now evaluating “strategic alternatives” for the company after a rocky few years.
The company announced Tuesday that the ongoing trials for its two GoCAR-T cell candidates in combination with rimiducid in pre-treated cancer patients, BPX-601 and BPX-603, are coming to a halt. This comes after a patient on BPX-601 experienced serious side effects, including grade 4 cytokine release syndrome. This was the second dose-limiting toxicity in the dose-escalation cohort.
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