‘Bio­hack­er’ Tray­wick dead at 28 — known for self-in­ject­ing a DIY her­pes drug

Con­tro­ver­sial bio­hack­er Aaron Tray­wick was found dead on Sun­day in a spa room in Wash­ing­ton, DC, ac­cord­ing to mul­ti­ple me­dia re­ports cit­ing the DC po­lice. He was 28.

Aaron Tray­wick

Tray­wick, the CEO of As­cen­dance Bio­med­ical, was known for his view that in­di­vid­u­als should be able to self-de­sign and self-ad­min­is­ter un­ap­proved treat­ments — like gene ther­a­py — with­out the re­quire­ment of a health­care pro­fes­sion­al. He gained wide pub­lic­i­ty in Feb­ru­ary when he in­ject­ed him­self with a DIY treat­ment that he hoped would cure his her­pes on­stage at a bio­hack­er con­fer­ence in Texas. The whole process was broad­cast live on Face­book.

Ac­cord­ing to News2Share, which first re­port­ed the news (and filmed Tray­wick in Feb­ru­ary), Tray­wick was found in a floata­tion tank — a sound­proof pod filled with body-tem­per­a­ture salt­wa­ter meant to pro­mote “sen­so­ry de­pri­va­tion” and “deep re­lax­ation.”

A death in­ves­ti­ga­tion is still on­go­ing, though law en­force­ment not­ed they have no ev­i­dence sug­gest­ing foul play at the mo­ment.

Last Oc­to­ber, Tray­wick at­tract­ed the at­ten­tion of the FDA by stag­ing a live demon­stra­tion of an untest­ed HIV treat­ment. Tris­tan Roberts, an HIV pa­tient, vol­un­teered to in­ject him­self with the pur­port­ed gene ther­a­py. Nei­ther of them had for­mal train­ing in med­i­cine or ge­net­ic en­gi­neer­ing. Short­ly there­after, with­out nam­ing names, the FDA is­sued a warn­ing against self-ad­min­is­tra­tion of gene ther­a­py prod­ucts, con­cerned about the safe­ty risks in­volved.

While he did not get the re­sults he want­ed (his vi­ral load rose in­stead of falling), Roberts pre­vi­ous­ly said he still be­lieved in the po­ten­tial of the ther­a­pies be­ing de­vel­oped.

“Aaron was a pas­sion­ate vi­sion­ary. He seem­ing­ly nev­er tired as he brought peo­ple to­geth­er to work on some of the most im­pos­ing chal­lenges fac­ing hu­man­i­ty,” Roberts said in a state­ment pro­vid­ed to Vice News. “While many in the bio­hack­ing scene dis­agreed with his meth­ods, none of them doubt­ed his in­ten­tions. He sought noth­ing short of a rev­o­lu­tion in bio­med­i­cine; the de­moc­ra­ti­za­tion of sci­ence and the open­ing of the flood gates for glob­al heal­ing.”

IDC: Life Sci­ences Firms Must Em­brace Dig­i­tal Trans­for­ma­tion Now

Pre-pandemic, the life sciences industry had settled into a pattern. The average drug took 12 years and $2.9 billion to bring to market, and it was an acceptable mode of operations, according to Nimita Limaye, Research Vice President for Life Sciences R&D Strategy and Technology at IDC.

COVID-19 changed that, and served as a proof-of-concept for how technology can truly help life sciences companies succeed and grow, Limaye said. She recently spoke about industry trends at Egnyte’s Life Sciences Summit 2022. You should watch the entire session, free and on-demand, but here’s a brief recap of why she’s urging life sciences companies to embrace digital transformation.

Martin Landray, Protas CEO (Illustration: Assistant Editor Kathy Wong for Endpoints News)

Those big bil­lion-dol­lar PhI­II stud­ies? Mar­tin Lan­dray says they can be done for a tiny frac­tion of the cost

Martin Landray knows what controversy in clinical drug development feels like, from first-hand experience.

Landray was the chief architect of RECOVERY, a study that pitted a variety of drugs against Covid-19. And he offered some landmark data that would help push dexamethasone out into broader use as a cheap treatment, while helping ice hydroxy’s reputation as a clear misfire.

“Lots of people told us we shouldn’t use it,” Landray says about dexamethasone and Covid-19. “It was dangerous. We shouldn’t even do a trial. They also cared about hydroxychloroquine and lots of people said we shouldn’t do a trial because it must be used. I’ve got the letters from both sets of people.”

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Geoffrey Porges, new Schrödinger CFO

Long­time an­a­lyst Ge­of­frey Porges de­parts SVB to lead fi­nances at a drug dis­cov­ery shop

Geoffrey Porges has ended his two-decade run as a biotech analyst, as the former SVB Securities vice chair began as CFO of Schrödinger on Thursday.

The long-running analyst, who previously headed up vaccines marketing at Merck before the turn of the millennium, will lead the financial operations of the 700-employee company as Schrödinger broadens its focus from a drug discovery partner to also building out an in-house pipeline, with clinical trial No. 1 set to begin next quarter.

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FDA ap­proves one of the prici­est new treat­ments of all time — blue­bird's gene ther­a­py for be­ta tha­lassemia

The FDA on Wednesday approved the first gene therapy for a chronic condition — bluebird bio’s new Zynteglo (beti-cel) as a potentially curative treatment for those with transfusion-dependent thalassemia.

The thumbs-up from the FDA follows a unanimous adcomm vote in June, with outside experts pointing to extraordinary efficacy, with 89% of subjects with TDT who received beti-cel having achieved transfusion independence.

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James Dentzer, Curis CEO

FDA lifts par­tial hold on Curis' lym­phoma study — shares spike

Four months after the FDA put two clinical trials from Curis on clinical hold, the FDA is now apparently content with how the biotech will change up managing one of the studies.

The Massachusetts oncology biotech put out word early Thursday that the federal regulator lifted a partial clinical hold of the company’s Phase I/II study of emavusertib in lymphoma, following a new data package that the biotech recently submitted to the agency. Shares of the biotech $CRIS, hovering just above penny stock territory, shot up more than 55% in early trading before settling at close to a 30% share price boost.

Astel­las' hot flash­es drug will get speedy re­view at FDA; US opts out of Val­ne­va vac­cine

The FDA will decide on Astellas’ menopausal symptom drug by Feb. 22 of next year, as the Japanese pharma disclosed it had paid about $97 million to get a priority review voucher to speed up the review.

Astellas said the agency has accepted the pharma’s application for fezolinetant for the treatment of moderate to severe vasomotor symptoms (VMS) associated with menopause. VMS includes hot flashes and/or night sweats. The company said as many as 80% of women in the US experience those symptoms during or after the menopausal transition.

James Mock, incoming CFO at Moderna

Mod­er­na taps new CFO from PerkinElmer af­ter for­mer one-day CFO oust­ed

When Moderna hired a new CFO last year,  it didn’t expect to see him gone after only one day. Today the biotech named his — likely much more vetted — replacement.

The mRNA company put out word early Wednesday that after the untimely departure of then brand-new CFO Jorge Gomez, it has now found a replacement in James Mock, the soon-to-be former CFO at diagnostics and analytics company PerkinElmer.

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Joel Dudley, new partner at Innovation Endeavors (Bosch Health Campus)

For­mer Google CEO’s VC is mak­ing a big­ger push in­to the biotech world, hir­ing promi­nent Ther­a­nos skep­tic

Venture capital firm Innovation Endeavors has mainly had its focus on investments across the tech space, but it has been slowly turning its attention to the biotech world. Now, a new partner is coming into the fold showing that its interest in biotech is likely to grow further.

The Silicon Valley-based company, which is headed up by former Google CEO Eric Schmidt, has brought on Joel Dudley as a partner. According to Dudley’s LinkedIn page, he is joining Innovation Endeavors after serving as the chief science officer of biotech startup Tempus Labs since 2020.

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Chris Sheldon, AstraZeneca's former VP and head of investor relations

As­traZeneca files law­suit against for­mer ex­ec as he jumps to GSK

AstraZeneca and GSK are once again wrangling over talent.

The British pharma giant has filed suit against former VP and head of investor relations Chris Sheldon as he prepares to start a new job at its rival next month. AstraZeneca argued in a London court filing that Sheldon would be violating a non-compete agreement, which he was paid more than $774,000 in shares to sign back in 2021, Bloomberg reported.