Biopharma's success rate in bringing drugs to market has long been abysmal. Can new tools help rewrite that troubled past?
In 2011, a team of researchers at British drugmaker AstraZeneca had a problem they were looking to solve.
For years, drug discovery and development were a wasteland for innovation. Novel drugs largely fell into one of two categories — monoclonal antibodies and small molecules — and new therapeutic modalities were hard to come by. After a rush of promising approvals in the late 1990s — including then-Biogen’s CD20 targeting antibody breakthrough Rituxan — the field stagnated and attrition rates stayed sky-high. What exactly is the industry doing wrong? AstraZeneca asked itself.
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