Bound for the clinic with a new approach to synthetic lethality, Cyteir bags $29M
As an associate professor at The Jackson Laboratory, Kevin Mills zeroed in on the supporting role that the RAD51 protein played in repairing the DNA damage caused by elevated levels of activation-induced cytidine deaminase, or AID.
Tripping up RAD51 with a small molecule, he thought, would throw a monkey wrench in the whole DNA repair pathway, allowing mutated cancer cells and other stressed cells involved in autoimmune diseases to die, playing an assisting role in synthetic lethality.
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