Cam­bridge star Ma­gen­ta teams up with Hei­del­berg on bone mar­row R&D pact that in­cludes $334M in po­ten­tial mile­stones

High-fly­ing Cam­bridge up­start Ma­gen­ta Ther­a­peu­tic has inked an ex­clu­sive deal with a Ger­man biotech to work on drugs that might im­prove bone mar­row trans­plants for pa­tients.

Ma­gen­ta is team­ing up with Hei­del­berg Phar­ma, com­bin­ing its stem cell plat­form with Hei­del­berg’s pro­pri­etary AT­AC (An­ti­body Tar­get­ed Aman­itin Con­ju­gates) plat­form. The duo will ap­ply their tech across up to four tar­gets, with the hope of de­vel­op­ing an­ti­body drug con­ju­gates.

Hei­del­berg is get­ting up­front tech ac­cess and ex­clu­siv­i­ty fees and pay­ments for re­search sup­port, al­though the de­tails weren’t dis­closed. We do know that Ma­gen­ta could pay up to $334 mil­lion in mile­stone pay­ments, should the com­pa­ny ex­er­cise all its tar­get op­tions and if all mile­stones are met.

The goal of the part­ner­ship is to find an­ti­bod­ies that would bet­ter pre­pare pa­tients for bone mar­row trans­plants. As it stands now, pa­tients must be “con­di­tioned” be­fore re­ceiv­ing trans­plants to pre­vent re­jec­tion of the in­com­ing stem cells. Con­di­tion­ing in­volves re­mov­ing all ex­ist­ing stem cells in the bone bar­row and dis­eased cells us­ing what Ma­gen­ta calls high­ly tox­ic agents and pro­ce­dures like ra­di­a­tion that kill cells in a non-spe­cif­ic way.

Ma­gen­ta sci­en­tists have shown that an­ti­bod­ies which rec­og­nize stem cells linked to drugs can be used to se­lec­tive­ly re­move stem cells and dis­eased cells.

Michael Cooke

“There is a sig­nif­i­cant need for tar­get­ed con­di­tion­ing reg­i­mens for bone mar­row trans­plant, and this is a key area of fo­cus for Ma­gen­ta,” said Ma­gen­ta’s CSO Michael Cooke in a state­ment. “Aman­itin is one of the promis­ing tox­ins we are ex­plor­ing in our tar­get­ed con­di­tion­ing pro­grams, and our part­ner­ship with Hei­del­berg Phar­ma will al­low us to ful­ly eval­u­ate the po­ten­tial of this pay­load.”

Ma­gen­ta, with its lofty goals of im­prov­ing stem cell trans­plan­ta­tion, has been mak­ing a splash in the big Cam­bridge/Boston hub, gath­er­ing $98.5 mil­lion in ven­ture cash from some mar­quee in­vestors that in­clude GV — the ven­ture group for­mer­ly known as Google Ven­tures — and in-li­cens­ing a mid-stage drug that No­var­tis thinks high­ly of for en­hanc­ing cord blood stem cells as a treat­ment. Just last month, the com­pa­ny re­cruit­ed Big Phar­ma R&D ex­ec John Davis, for­mer­ly of Pfiz­er, to serve as Ma­gen­ta’s new chief med­ical of­fi­cer.

As­traZeneca trum­pets the 'mo­men­tous' da­ta they found for Tagris­so in an ad­ju­vant set­ting for NSCLC — but many of the ex­perts aren’t cheer­ing along

AstraZeneca is rolling out the big guns this evening to provide a salute to their ADAURA data on Tagrisso at ASCO.

Cancer R&D chief José Baselga calls the disease-free survival data for their drug in an adjuvant setting of early stage, epidermal growth factor receptor-mutated NSCLC patients following surgery “momentous.” Roy Herbst, the principal investigator out of Yale, calls it “transformative.”

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Paul Hudson, Sanofi CEO (Getty Images)

Sanofi CEO Paul Hud­son has $23B burn­ing a hole in his pock­et. And here are some hints on how he plans to spend that

Sanofi has reaped $11.1 billion after selling off a big chunk of its Regeneron stock at $515 a share. And now everyone on the M&A side of the business is focused on how CEO Paul Hudson plans to spend it.

After getting stung in France for some awkward politicking — suggesting the US was in the front of the line for Sanofi’s vaccines given American financial support for their work, versus little help from European powers — Hudson now has the much more popular task of managing a major cash cache to pull off something in the order of a big bolt-on. Or two.

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The Avance Clinical leadership team: CEO Yvonne Lungershausen, Sandrien Louwaars - Director Business Development Operations, Gabriel Kremmidiotis - Chief Scientific Officer, Ben Edwards - Chief Strategy Officer

How Aus­tralia De­liv­ers Rapid Start-up and 43.5% Re­bate for Ear­ly Phase On­col­o­gy Tri­als

About Avance Clinical

Avance Clinical is an Australian owned Contract Research Organisation that has been providing high-quality clinical research services to the local and international drug development industry for 20 years. They specialise in working with biotech companies to execute Phase 1 and Phase 2 clinical trials to deliver high-quality outcomes fit for global regulatory standards.

As oncology sponsors look internationally to speed-up trials after unprecedented COVID-19 suspensions and delays, Australia, which has led the world in minimizing the pandemic’s impact, stands out as an attractive destination for early phase trials. This in combination with the streamlined regulatory system and the financial benefits including a very favourable exchange rate and the R & D cash rebate makes Australia the perfect location for accelerating biotech clinical programs.

Pablo Legorreta, founder and CEO of Royalty Pharma AG, speaks at the annual Milken Institute Global Conference in Beverly Hills, California (Patrick T. Fallon/Bloomberg via Getty Images)

Cap­i­tal­iz­ing Pablo: The world’s biggest drug roy­al­ty buy­er is go­ing pub­lic. And the low-key CEO di­vulges a few se­crets along the way

Pablo Legorreta is one of the most influential players in biopharma you likely never heard of.

Over the last 24 years, Legorreta’s Royalty Pharma group has become, by its own reckoning, the biggest buyer of drug royalties in the world. The CEO and founder has bought up a stake in a lengthy list of the world’s biggest drug franchises, spending $18 billion in the process — $2.2 billion last year alone. And he’s become one of the best-paid execs in the industry, reaping $28 million from the cash flow last year while reserving 20% of the cash flow, less expenses, for himself.

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As­traZeneca’s $7B ADC suc­ceeds where Roche failed, im­prov­ing sur­vival in gas­tric can­cer

Another day, another win for Enhertu.

The antibody-drug conjugate AstraZeneca promised up-to $7 billion to partner on has had a quite a few months, beginning with splashy results in a Phase II breast cancer trial, a rapid approval and, earlier this month, breakthrough designations in both non-small cell lung cancer and gastric cancer.

Now, at ASCO, the British pharma and their Japanese partner, Daiichi Sankyo, have shown off the data that led to the gastric cancer designation, which they’ll take back to the FDA. In a pivotal, 187-person Phase II trial, Enhertu shrunk tumors in 42.9% of third-line patients with HER2-positive stomach cancer, compared with 12.5% in a control arm where doctors prescribed their choice of therapy. Progression-free survival was 5.4 months for Enhertu compared to 3.5 months for the control.

David Chang, Allogene CEO (Jeff Rumans)

Head­ed to PhII: Al­lo­gene CEO David Chang com­pletes a pos­i­tive ear­ly snap­shot of their off-the-shelf CAR-T pi­o­neer

Allogene CEO David Chang has completed the upbeat first portrait of the biotech’s off-the-shelf CAR-T contender ALLO-501 at virtual ASCO today, keeping all eyes on a drug that will now try to go on to replace the first-wave personalized pioneers he helped create.

The overall response rate outlined in Allogene’s abstract for treatment-resistant patients with non-Hodgkin lymphoma slipped a little from the leadup, but if you narrow the patient profile to treatment-naïve patients — removing the 3 who had previous CAR-T therapy who didn’t respond, leaving 16 — the ORR lands at 75% with a 44% complete response rate. And 9 of the 12 responders remained in response at the data cutoff, offering a glimpse on durability that still has a long way to go before it can be completely nailed down.

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Once a gem, now just a rock, Take­da punts PhI­II IBD drug as ri­vals mus­cle ahead

Back in 2016, when then-Shire CEO Flemming Ørnskov picked up a promising clinical-stage IBD drug from Pfizer, the Boston-based biotech dubbed it SHP647 and moved it into the gem section of the pipeline, with rosy expectations of registration-worthy Phase III data ahead.

This was a drug that the EC wanted Takeda to commit to selling off before it gave their blessing to its acquisition of Shire, to settle some deep-seated concerns revolving around the potential market overlap with their blockbuster rival Entyvio. And Takeda, which took on a heavy debt load to buy Shire, clearly wanted the cash to pay down debt.

Ear­ly sur­vival da­ta boost Zio­phar­m's 'con­trolled IL-12' im­munother­a­py for glioblas­toma

An unconventional pairing of a gene therapy and an oral drug that promises to attack recurrent or progressive glioblastoma with controlled release of IL-12 has turned up more promising — if early — overall survival data. On top of boosting its case as a monotherapy, the data can also bode well for a combination with Regeneron’s PD-1 inhibitor, Libtayo.

Both the treatment and its developer, Ziopharm Oncology, have come a long way. The stock price peaked in 2015 but cratered in 2016 following a patient death in a Phase I.

As tislelizum­ab gains trac­tion in Chi­na, BeiGene pulls the cur­tain on NSCLC da­ta sup­port­ing the PD-1 drug

In a world now brimming with checkpoint inhibitors, companies often struggle to make a mark given a raft of therapies have already captured a considerable portion of the vast oncology market.

BeiGene’s tislelizumab was the fourth PD(L)-1 inhibitor to secure approval in China — and as it works on expanding its share the company has put out detailed data on the use of the drug in certain patients with lung cancer.