Can Am­gen beat down pay­er re­sis­tance to Repatha with its own cost analy­sis?

PC­SK9 heart drugs have proven to be one of the biggest com­mer­cial dis­ap­point­ments in re­cent bio­phar­ma times. Held back by pay­ers who don’t see the val­ue in pro­vid­ing the drugs even at a hefty 30% or so dis­count on the list price, sales of Am­gen’s Repatha and Pralu­ent from Re­gen­eron/Sanofi have lan­guished — fur­ther ham­pered by cost analy­sis stud­ies that as­cribe a rel­a­tive­ly small val­ue to the drugs.

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