CAR macrophage tu­mor tech cre­at­ed by UPenn star sci­en­tists gets $53M

A cou­ple of star sci­en­tists at UPenn just got fi­nan­cial back­ing from Ab­b­Vie and oth­er in­vestors to come at sol­id tu­mors in an un­usu­al way: re-en­gi­neer­ing macrophages to eat up can­cer cells.

The Philadel­phia-based com­pa­ny was first chris­tened “Car­ma Ther­a­peu­tics” when it launched last year, but thanks to pesky trade­mark con­flicts its step­ping out to­day with a new moniker: Caris­ma Ther­a­peu­tics. And the new name comes with $53 mil­lion in a Se­ries A round led by Ab­b­Vie Ven­tures and Health­Cap.

Saar Gill

Loaded with ca­chet among can­cer re­searchers, the com­pa­ny’s found­ing team in­cludes Saar Gill, a ris­ing ex­pert in CAR-T cells and an as­sis­tant pro­fes­sor at Penn’s Abram­son Can­cer Cen­ter. But Caris­ma’s CEO Steven Kel­ly tells me the com­pa­ny’s tech plat­form was large­ly built on PhD can­di­date Michael Klichin­sky’s the­sis. Klichin­sky, who co-found­ed Caris­ma, count­ed both Gill and Penn’s can­cer lu­mi­nary Carl June as his ad­vi­sors. And the com­pa­ny man­aged to bring June, who launched his own can­cer start­up Tmu­ni­ty ear­li­er this year, on­to its sci­en­tif­ic ad­vi­so­ry board.

Caris­ma is work­ing in a very dif­fer­ent space than Tmu­ni­ty, Kel­ly said, but their goal is com­mon enough: get ther­a­peu­tics in­to sol­id tu­mors.

Steven Kel­ly

“CAR-T has pro­found re­sults in hema­to­log­i­cal ma­lig­nan­cy, but it has a dif­fi­cult time reach­ing the site of the tu­mor,” Kel­ly said. “If it does reach the tu­mor site, it’s met with an im­muno­sup­pres­sive en­vi­ron­ment.”

This is not the case for macrophages. These blob­by-look­ing phago­cyt­ic cells are the Pac­man of the body, sleuthing blood and tis­sue, seek­ing out pro­teins or cells that need to be nixed. They in­fil­trate tis­sue and hang out there, de­vour­ing cells as need­ed. Since these cells have no trou­ble reach­ing the tu­mor site, Caris­ma is hop­ing to har­vest them, re-en­gi­neer them with CAR tar­get­ing tech, and de­liv­er them back to the pa­tient.

“We’ve demon­strat­ed that these cells will traf­fic to the site of the tu­mor,” Kel­ly said. “In fact, half the cells there are macrophages.”

With the com­pa­ny’s new pro­ceeds, Caris­ma will take its tech through pre­clin­i­cal de­vel­op­ment, IND, and en­ter Phase I test­ing by 2019, Kel­ly said. The ex­cess funds will go to­wards build­ing a pipeline of on­col­o­gy drugs and ex­plor­ing oth­er ar­eas pro­tein degra­da­tion might be use­ful. Plus, they’re 5-per­son team must ex­pand. They’re hunt­ing for a new CSO and CMO, and plan to hire 20 FTEs over the next 12 months.

Im­age: Michael Klichin­sky (CARIS­MA)

Paul Hudson, Sanofi CEO (Cyril Marcilhacy/Bloomberg via Getty Images)

FDA side­lines Paul Hud­son's $3.7B MS drug af­ter es­tab­lish­ing link to liv­er dam­age

One of Sanofi CEO Paul Hudson’s top picks in the pipeline — picked up in a $3.7 billion buyout 2 years ago — has just been sidelined in the US by a safety issue.

The pharma giant put out word early Thursday that the FDA has put their Phase III studies of tolebrutinib in multiple sclerosis and myasthenia gravis on partial clinical hold, halting enrollment and suspending dosing for patients who have been on the drug for less than 60 days. Patients who have completed at least 60 days of treatment can continue therapy as researchers explore a “limited” — but unspecified in Sanofi’s statement — number of cases of liver injury.

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Phar­ma re­acts to post-Roe; Drug­mak­ers beef up cy­ber de­fense; Boehringer, Roche qui­et­ly axe drugs; and more

Welcome back to Endpoints Weekly, your review of the week’s top biopharma headlines. Want this in your inbox every Saturday morning? Current Endpoints readers can visit their reader profile to add Endpoints Weekly. New to Endpoints? Sign up here.

As a reminder, we are off on Monday for the Fourth of July. I hope this recap will kick off your (long) weekend well and that the rest of it will be just what you need. See you next week for a shortened edition!

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Eric Hughes, incoming Teva EVP of global R&D and CMO

Te­va chief raids Ver­tex for his new glob­al head of re­search and de­vel­op­ment

Teva CEO Kåre Schultz has found his new R&D chief and CMO in Vertex’s ranks.

The global generics giant, which has some 3,500 staffers in the R&D group, has named Eric Hughes to the top research spot in the company. He’ll be replacing Hafrun Fridriksdottir, who held the role for close to five years, on Aug. 1.

Hughes hasn’t been at Vertex for long, though. He jumped from Novartis less than a year ago, after heading the immunology, hepatology & dermatology global development unit. Before that, he completed a five-year stint as head of early clinical research for the specialty discovery medicine department in the exploratory clinical & translational research group at Bristol Myers Squibb, according to his LinkedIn profile.

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#BIO22: Man­ag­ing a biotech in tur­bu­lent times. 'There's a per­fect shit­show out there'

On Tuesday, June 14, Endpoints News EIC John Carroll sat down with a group of biotech execs to discuss the bear market for industry stocks and how they were dealing with it. Here’s the conversation, which has been lightly edited for brevity.

Martin Meeson, sponsor opening:

Thank you, John. Hello everyone. My name’s Martin Meeson, I’m the CEO of Fujifilm Diosynth. For those of you who don’t know Fujifilm Diosynth, we operate in the development of clinical and commercial product scale up, we have facilities in Europe and the US, and around about 4,000 employees. We run on average about 150 programs, so when it comes to managing in turbulent times over the last two years, we’ve had quite a lot of experience of that. Not just keeping the clinical pipelines and the commercial pipelines open, but also our response to the pandemic and the molecules that we’ve had within there. One of the phrases that I coined probably about a year ago when we were talking at JP Morgan, was I talked about managing through turbulent times. Well, it’s become the fact that we are not managing and leading through these times, we are managing in them, which is why that’s really the purpose of and the topic that we’ve got today.

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On Friday, Lonza announced plans to construct a large-scale commercial drug product fill and finish facility in the town of Stein, Switzerland.

Lon­za to in­vest $500M+ on fill-fin­ish fa­cil­i­ty on its home turf

Lonza has been expanding its reach across the globe, bringing sites in China and the US online this year, but now they are looking closer to home for their next major investment.

The Swiss manufacturer on Friday announced plans to construct a large-scale commercial drug fill and finish facility in the town of Stein, Switzerland. The new facility will be delivered through an investment of approximately CHF 500 million, or $519 million, and is expected to be completed in 2026. The facility will also be constructed on the same campus as Lonza’s current clinical drug product facility.

Kate Haviland, Blueprint Medicines CEO

What bear mar­ket? Blue­print lines up $1.25B to ex­pand la­bels, maybe tack on more drugs

As it works to pad the case for expanding its Ayvakit and Gavreto labels, Blueprint Medicines has lined up $1.25 billion in funding, with some of that money seemingly earmarked for acquisitions or pipeline expansion projects.

Following the likes of BioCryst, Cytokinetics and MorphoSys, Blueprint is aiming to monetize the royalties of its RET+ non-small cell lung cancer and thyroid cancer drug Gavreto with Royalty Pharma. The investment group will dole out $175 million upfront and might tack on another $165 million in biobucks as part of Blueprint’s royalties receivable from net sales of the drug by Roche outside the US, sans China.

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Fu­ji­film in­vests an­oth­er $1.6B in­to its CD­MO arm to up­grade facil­lites in the US and Eu­rope

Fujifilm’s spending spree into its CDMO arm is not slowing down.

The multinational announced on Wednesday that it will invest $1.6 billion to enhance and expand the cell culture manufacturing services of the CDMO arm of the Japanese conglomerate Fujifilm Diosynth.

The investment will enhance Fujifilm Diosynth Biotechnologies’ sites in Hillerød, Denmark, and College Station, TX. The investment is expected to create approximately 450 jobs across both facilities.

Anand Parikh, Faeth Therapeutics CEO

Sid Mukher­jee, Lew Cant­ley be­hind new can­cer biotech with food+drug com­bo treat­ment am­bi­tions 

Famed oncologist Sid Mukherjee and repeat biotech co-founder Lew Cantley have teamed up to form Faeth Therapeutics, a startup aiming to treat cancer the way other conditions are addressed: pairing nutrition with therapeutics.

The goal is to transform cancer treatment with nutrition and make it the fourth “pillar” in the oncology regimen, which to date has centered on radiotherapy, surgery and drugs, Faeth CEO Anand Parikh told Endpoints News. Other conditions have already been addressed with a side of nutrients or diet, he said, pointing to diabetes, irritable bowel syndrome and other diseases.

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Amgen's taking social media followers around the globe as it introduces the many different

From Tam­pa to Mu­nich, Am­gen’s ‘Places’ cam­paign in­tro­duces its lo­ca­tions around the world

Amgen is taking social media followers around the world with its latest corporate campaign. Called “Places of Amgen,” the twice monthly posts highlight the biopharma’s different offices and sites – and the people who work there.

Each post runs on LinkedIn, Facebook and Instagram with details about the work Amgen does in that location, when it was established, comments from people who work there and other interesting facts. The most recent one about Paris, France, for example, notes that Amgen France last year signed a French association charter committed to the inclusion of LBGT+ people in the workplace.

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