Celyad gets the go-ahead to resume CAR-T trial for colorectal cancer as FDA lifts hold
Four months ago, the FDA placed a clinical hold on Celyad’s CAR-T trial for colorectal cancer after two patients died during the study. Regulators have now lifted the hold, allowing the Belgian company’s trial to set sail once again.
On Feb. 28, Celyad announced that it had “voluntarily paused” the trial of its off-the-shelf CAR-T in combination with Merck’s PD-1 inhibitor Keytruda as it investigated the deaths. Both patients had “presented with similar pulmonary findings,” the company added without further explanation. The FDA imposed the hold shortly after the company’s announcement.
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