Checkpoint combos for cancer are all the rage as trial sponsors line up hundreds of new studies — report
Number of Anti-PD-1/PD-L1 MAb combination studies 2015 vs. 2017
Full Report: Evaluate Ltd. May 2017
Over the last few months it hasn’t been unusual to see new combination studies being announced on a daily basis, matching one of the 5 approved PD-(L)1 checkpoint drugs with another cancer therapy. Some mornings they come in pairs.
It’s not hard to see why. The checkpoints typically work as a monotherapy — though there have been some nasty setbacks over the past 6 months. And some of the big players are happy to contribute their drug to studies sponsored by others looking to advance a pilot Phase I/II exploratory study. There are also recent examples of some big tie-ups between Merck (Keytruda) and Bristol-Myers Squibb (Opdivo) checkpoints with Incyte in Phase III.
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