Discovery by Shanghai scientists inspires new plan of ATTEC for protein degradation
In a review penned weeks ago, Craig Crews — the Yale scientist credited with the discovery of PROTACs — reflected on how, in the two decades since he helped launch the field, targeted protein degradation has moved beyond the proteasome into “novel and exciting” strategies.
“For example, Lysosome Targeting Chimeras (LYTACs) harness the lysosomal degradation pathway to induce degradation of extracellular proteins and the Macroautophagy Degradation Targeting Chimera (MADTAC) platforms, AUTACs and ATTECs hijack the autophagy pathway, thus potentially enabling the targeted destruction of entire organelles and protein aggregates,” he and co-author Michael Bond wrote.
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