End­points In­sid­er: The world’s old­est new biotech pub ends its 12th month on a roll

We’ve been watch­ing our web traf­fic grow month-to-month at a dou­ble-dig­it pace. In June, traf­fic at End­points News hit 313,439, ex­act­ly 10% high­er than the month be­fore, with 161,226 unique vis­i­tors to the site. And our sub­scriber list broke the 16,000 mark – heav­i­ly con­cen­trat­ed among bio­phar­ma ex­ec­u­tives — as we head straight to 20,000 this fall.

I like to say that End­points is the old­est new bio­phar­ma pub on the block. For those of you who have fol­lowed me over the past 15 years – in­clud­ing much of the 14 years be­fore Ar­salan Arif and I part­nered on the launch on June 20, 2016 – it’s that track record and abil­i­ty to swift­ly add con­text to the news that makes this pub dif­fer­ent from all of the rest. And as we grow the staff this sum­mer, you can bet that we’ll be look­ing to con­tin­ue to broad­en our cov­er­age base and ge­o­graph­ic reach as we look to grow the au­di­ence and web traf­fic to 500,000-plus in the near fu­ture.


What I’m par­tic­u­lar­ly hap­py about is that we ac­com­plished this with a small team and ex­act­ly noth­ing to spend on a mar­ket­ing cam­paign. All of our growth has been through word-of-mouth rec­om­men­da­tions and our so­cial me­dia pres­ence, with a big boost re­cent­ly from Google News. When you’re boot-strap­ping a new, dig­i­tal pub like this, you’ve got noth­ing ex­tra for mar­ket­ing. So we’re all ex­tra­or­di­nar­i­ly grate­ful for your sup­port and the steady stream of notes from read­ers.

This lit­er­al­ly could nev­er have hap­pened with­out your help.

To help fund the sec­ond year of growth, Ar­salan and I are prep­ping a sub­scriber cam­paign for End­points In­sid­er that will get un­der­way ear­ly next week. As we’ve al­ready made clear, we are not go­ing be­hind a pay­wall. The news will re­main on­line and eas­i­ly ac­ces­si­ble. We are look­ing for read­ers who sup­port the mis­sion, or sim­ply no longer wish to get emailed ad­ver­tis­ing, to sub­scribe to End­points for $200 a year.

Pre-reg­is­ter for End­points In­sid­er

No pay­ment de­tails re­quired to­day

There’s al­so a $1,000/per year cor­po­rate rate for groups, no mat­ter what size. That in­cludes full reprint and re­pub­lish­ing rights of our con­tent for all le­git­i­mate busi­ness cas­es — per­fect for PR agen­cies who want to send ar­ti­cles in full to clients, cor­po­rate in­tranets, trade show ad­ver­tis­ing, web­site post­ing, and more. Whether you are a multi­na­tion­al cor­po­ra­tion or a small shop, the en­ter­prise rate is the same.

We’ve had a strong re­sponse from our first word on this new cam­paign. And you can add your name to our pre­reg­is­tra­tion list here. (You won’t be billed to­day or asked to pro­vide pay­ment de­tails.)

It’s been a great start. And the rest of 2017 and all of 2018 are go­ing to be gang­busters. I guar­an­tee you won’t want to miss it. — John Car­roll

Norbert Bischofberger. Kronos

Backed by some of the biggest names in biotech, Nor­bert Bischof­berg­er gets his megaround for plat­form tech out of MIT

A little over a year ago when I reported on Norbert Bischofberger’s jump from the CSO job at giant Gilead to a tiny upstart called Kronos, I noted that with his connections in biotech finance, that $18 million launch round he was starting off with could just as easily have been $100 million or more.

With his first anniversary now behind him, Bischofberger has that mega-round in the bank.

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Chas­ing Roche's ag­ing block­buster fran­chise, Am­gen/Al­ler­gan roll out Avastin, Her­ceptin knock­offs at dis­count

Let the long battle for biosimilars in the cancer space begin.

Amgen has launched its Avastin and Herceptin copycats — licensed from the predecessors of Allergan — almost two years after the FDA had stamped its approval on Mvasi (bevacizumab-awwb) and three months after the Kanjinti OK (trastuzumab-anns). While the biotech had been fielding biosimilars in Europe, this marks their first foray in the US — and the first oncology biosimilars in the country.

Seer adds ex-FDA chief Mark Mc­Clel­lan to the board; Her­cules Cap­i­tal makes it of­fi­cial for new CEO Scott Bluestein

→ On the same day it announced a $17.5 million Series C, life sciences and health data company Seer unveiled that it had lured former FDA commissioner and ex-CMS administrator Mark McClellan on to its board. “Mark’s deep understanding of the health care ecosystem and visionary insights on policy reform will be crucial in informing our thinking as we work to bring our liquid biopsy and life sciences products to market,” said Seer chief and founder Omid Farokhzad in a statement.

Francesco De Rubertis

Medicxi is rolling out its biggest fund ever to back Eu­rope's top 'sci­en­tists with strange ideas'

Francesco De Rubertis built Medicxi to be the kind of biotech venture player he would have liked to have known back when he was a full time scientist.

“When I was a scientist 20 years ago I would have loved Medicxi,’ the co-founder tells me. It’s the kind of place run by and for investigators, what the Medicxi partner calls “scientists with strange ideas — a platform for the drug hunter and scientific entrepreneur. That’s what I wanted when I was a scientist.”

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Af­ter a decade, Vi­iV CSO John Pot­tage says it's time to step down — and he's hand­ing the job to long­time col­league Kim Smith

ViiV Healthcare has always been something unique in the global drug industry.

Owned by GlaxoSmithKline and Pfizer — with GSK in the lead as majority owner — it was created 10 years ago in a time of deep turmoil for the field as something independent of the pharma giants, but with access to lots of infrastructural support on demand. While R&D at the mother ship inside GSK was souring, a razor-focused ViiV provided a rare bright spot, challenging Gilead on a lucrative front in delivering new combinations that require fewer therapies with a more easily tolerated regimen.

They kept a massive number of people alive who would otherwise have been facing a death sentence. And they made money.

And throughout, John Pottage has been the chief scientific and chief medical officer.

Until now.

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Daniel O'Day

No­var­tis hands off 3 pre­clin­i­cal pro­grams to the an­tivi­ral R&D mas­ters at Gilead

Gilead CEO Daniel O’Day’s new task hunting up a CSO for the company isn’t stopping the industry’s dominant antiviral player from doing pipeline deals.

The big biotech today snapped up 3 preclinical antiviral programs from pharma giant Novartis, with drugs promising to treat human rhinovirus, influenza and herpes viruses. We don’t know what the upfront is, but the back end has $291 million in milestones baked in.

Vas Narasimhan, AP Images

On a hot streak, No­var­tis ex­ecs run the odds on their two most im­por­tant PhI­II read­outs. Which is 0.01% more like­ly to suc­ceed?

Novartis CEO Vas Narasimhan is living in the sweet spot right now.

The numbers are running a bit better than expected, the pipeline — which he assembled as development chief — is performing and the stock popped more than 4% on Thursday as the executive team ran through their assessment of Q2 performance.

Year-to-date the stock is up 28%, so the investors will be beaming. Anyone looking for chinks in their armor — and there are plenty giving it a shot — right now focus on payer acceptance of their $2.1 million gene therapy Zolgensma, where it’s early days. And CAR-T continues to underperform, but Novartis doesn’t appear to be suffering from it.

So what could go wrong?

Actually, not much. But Tim Anderson at Wolfe pressed Narasimhan and his development chief John Tsai to pick which of two looming Phase III readouts with blockbuster implication had the better odds of success.

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On a glob­al romp, Boehringer BD team picks up its third R&D al­liance for Ju­ly — this time fo­cused on IPF with $50M up­front

Boehringer Ingelheim’s BD team is on a global deal spree. The German pharma company just wrapped its third deal in 3 weeks, going back to Korea for its latest pipeline pact — this time focused on idiopathic pulmonary fibrosis.

They’re handing over $50 million to get their hands on BBT-877, an ATX inhibitor from Korea’s Bridge Biotherapeutics that was on display at a science conference in Dallas recently. There’s not a whole lot of data to evaluate the prospects here.

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Servi­er scoots out of an­oth­er col­lab­o­ra­tion with Macro­Gen­ics, writ­ing off their $40M

Servier is walking out on a partnership with MacroGenics $MGNX — for the second time.

After the market closed on Wednesday MacroGenics put out word that Servier is severing a deal — inked close to 7 years ago — to collaborate on the development of flotetuzumab and other Dual-Affinity Re-Targeting (DART) drugs in its pipeline.

MacroGenics CEO Scott Koenig shrugged off the departure of Servier, which paid $20 million to kick off the alliance and $20 million to option flotetuzumab — putting a heavily back-ended $1 billion-plus in additional biobuck money on the table for the anti-CD123/CD3 bispecific and its companion therapies.