Se­nior R&D ex­ec Sue Dil­lon jumps ship at J&J, launch­es mys­tery biotech start­up Aro with Cen­tyrins tech

Two for­mer ex­ec­u­tive heavy­weights at John­son & John­son have left the phar­ma gi­ant to launch a rather stealthy start­up called Aro Bio­ther­a­peu­tics – and they are start­ing out with some drug tech they’re al­ready close­ly fa­mil­iar with.

Karyn O’Neil

The com­pa­ny’s pres­i­dent and CEO is Sue Dil­lon, an R&D cham­pi­on and the ex-glob­al ther­a­peu­tic area head for im­munol­o­gy in the Janssen Phar­ma­ceu­ti­cals unit of J&J. Her co-founder and CSO is Karyn O’Neil, the for­mer ven­ture leader for Cen­tyrex, an­oth­er J&J unit.

The com­pa­ny is fly­ing deeply un­der the radar, with vir­tu­al­ly no web pres­ence aside from Bio­Cen­tu­ry’s news of Aro’s launch. Dil­lon did not im­me­di­ate­ly re­spond to our re­quest for more in­fo on the com­pa­ny, but here’s what we do know:

Aro is work­ing with a nov­el class of al­ter­na­tive scaf­fold mol­e­cules called Cen­tyrins, which can be en­gi­neered to bind to tar­get pro­teins with an in­ter­face of sim­i­lar size to those used by an­ti­bod­ies. This tech was be­ing de­vel­oped at Cen­tyrex (the J&J unit where O’Neil, the in­ven­tor of the Cen­tyrin plat­form, pre­vi­ous­ly worked), and that plat­form has been li­censed out to two can­cer com­pa­nies: On­tario-based Fu­sion Phar­ma­ceu­ti­cals and San Diego-based Po­sei­da Ther­a­peu­tics, the lat­ter of which was housed in J&J’s San Diego JLABs back in 2015. Fu­sion is de­vel­op­ing Cen­tyrin-based al­pha-par­ti­cle ra­dio­ther­a­peu­tics, and Po­sei­da is de­vel­op­ing au­tol­o­gous T cell and NK cell ther­a­pies that ex­press Cen­tyrins or Cen­tyrin CAR mol­e­cules.

Ac­cord­ing to J&J: “Aro Bio­ther­a­peu­tics has ex­clu­sive world­wide rights to the Cen­tyrin IP es­tate with Janssen re­served fields in­clud­ing and pur­suant to Fu­sion Phar­ma­ceu­ti­cals Inc. and Po­sei­da Ther­a­peu­tics Inc.”

Dil­lon and O’Neil join the great mi­gra­tion out of Big Phar­ma and in­to small biotech, as es­teemed R&D lead­ers in­creas­ing­ly seek op­por­tu­ni­ties else­where. O’Neil re­tired from her role at Cen­tyrex back in De­cem­ber, ac­cord­ing to her LinkedIn, to co-found Aro with Dil­lon. As for Dil­lon, she left her role at J&J around the same time.

New­man Yeild­ing

“Hav­ing sup­port­ed Sue for many years dur­ing her tenure here at Janssen/J&J, I have a great deal of re­spect for her lead­er­ship, vi­sion and de­ter­mi­na­tion to con­tin­ue to make a dif­fer­ence in pa­tients’ lives and in the life sci­ences in­dus­try,” wrote J&J’s glob­al ther­a­peu­tic area com­mu­ni­ca­tion leader Bri­an Ken­ney in an email.

Ken­ney not­ed that Dil­lon re­tired from J&J af­ter a “16 year suc­cess­ful ca­reer” with the com­pa­ny.

Ken­ney says New­man Yeild­ing, head of im­munol­o­gy de­vel­op­ment at Janssen, is lead­ing the ther­a­peu­tic area for im­munol­o­gy un­til the com­pa­ny finds a re­place­ment for Dil­lon.


Im­age: Sue Dil­lon. Janssen

Illustration: Assistant Editor Kathy Wong for Endpoints News

How Pur­due's $272M ad­dic­tion pay­out fund­ed a new home for its dis­card­ed non-opi­oid re­search

Don Kyle spent more than 20 years working for Purdue Pharma, right through the US opioid epidemic that led to the company’s rise and eventual infamy. But contrary to Purdue’s focus on OxyContin, Kyle was researching non-opioid painkillers — that is, until the company shelved his research.

As the company’s legal troubles mounted, Kyle found an unlikely way to reboot the project. In 2019, he took his work to an Oklahoma State University center that’s slated to receive more than two-thirds of the state’s $272 million settlement with Purdue over claims that the drugmaker’s behavior ignited the epidemic of opioid use and abuse.

Endpoints Premium

Premium subscription required

Unlock this article along with other benefits by subscribing to one of our paid plans.

President Joe Biden at the State of the Union address with Vice President Kamala Harris and House Speaker Kevin McCarthy (Patrick Semansky/AP Images)

The drug pric­ing pres­i­dent: Biden warns of ve­to for any IRA re­peal at­tempts

President Joe Biden made clear in his “finish the job” State of the Union address last night that one of those jobs to be finished is insulin prices.

Biden’s push again to tackle insulin prices, after Republicans rebuffed the idea last summer and just after Biden won Medicare drug price negotiations/caps via the Inflation Reduction Act, shows how heavily he’s leaning into this work.

Rupert Vessey, Bristol Myers Squibb head of research and early development

Up­dat­ed: R&D tur­bu­lence at Bris­tol My­ers now in­cludes the end of a $650M al­liance and the de­par­ture of a top re­search cham­pi­on

This morning biotech Dragonfly put out word that Bristol Myers Squibb has handed back all rights to its IL-12 clinical-stage drug after spending $650 million to advance it into the clinic.

The news arrives amid a turbulent R&D stage for the pharma giant, which late last week highlighted Rupert Vessey’s decision to depart this summer as head of early-stage R&D following a crucial three-year stretch after he jumped to Bristol Myers in the big Celgene buyout. During that time he struck a series of deals for Bristol Myers, and also shepherded a number of Celgene programs down the pipeline, playing a major role for a lineup of biotechs which depended on him to champion their drugs.

Endpoints Premium

Premium subscription required

Unlock this article along with other benefits by subscribing to one of our paid plans.

Bill Haney, Dragonfly CEO (Dave Pedley/Getty Images for SXSW)

Drag­on­fly chief: Bris­tol My­ers shouldn’t blame IL-12’s clin­i­cal per­for­mance for de­ci­sion to scrap the deal — eco­nom­ics played a key role

Bristol Myers Squibb says the IL-12 drug they were developing out of Dragonfly Therapeutics was scrubbed from the pipeline for a simple reason: It didn’t measure up on clinical performance.

But Bill Haney, the CEO of Dragonfly, is taking issue with that.

The early-stage drug, still in Phase I development, has passed muster with Bristol Myers’ general clinical expectations, advancing successfully while still in Phase I, he says.

Endpoints Premium

Premium subscription required

Unlock this article along with other benefits by subscribing to one of our paid plans.

Utpal Koppikar, new Verily CFO

Ex­clu­sive: Ver­i­ly wel­comes Atara Bio­ther­a­peu­tics vet­er­an as new CFO

Verily, Alphabet’s life sciences outfit, has plucked a new CFO from the ranks of Atara Biotherapeutics, the company announced on Wednesday.

Utpal Koppikar joins Verily after a nearly five-year stint as CFO and senior VP at Atara, though his résumé also boasts roles at Gilead and Amgen.

The news follows a major reshuffling at Verily, including several senior departures earlier this year and a round of layoffs.

Endpoints News

Keep reading Endpoints with a free subscription

Unlock this story instantly and join 159,000+ biopharma pros reading Endpoints daily — and it's free.

Singer Nick Jonas is back at work for Dexcom, this time for its new G7 glucose monitor.

Dex­com's spokescelebri­ty Nick Jonas re­turns to Su­per Bowl in new glu­cose mon­i­tor com­mer­cial

Dexcom is going back to the Super Bowl with its pop singer and patient spokesperson Nick Jonas. Jonas takes center stage as the lone figure in the 30-second commercial showcasing Dexcom’s next-generation G7 continuous glucose monitoring (CGM) device.

Jonas’ sleight-of-hand tricks populate the commercial — he pinches his empty fingers together and pops them open to reveal the small CGM — even as he ends the ad, saying, “It’s not magic. It just feels that way.” Jonas then disappears in a puff of smoke.

Endpoints News

Keep reading Endpoints with a free subscription

Unlock this story instantly and join 159,000+ biopharma pros reading Endpoints daily — and it's free.

Richard Francis, newly-appointed Teva CEO (Novartis via Facebook)

New Te­va CEO Richard Fran­cis repri­or­i­tizes to 'get back to growth'

Six weeks into his new role at the helm of Teva Pharmaceutical, Richard Francis said it’s time to “get back to growth,” starting with a good look at the company’s priorities.

The chief executive has kicked off a strategic review, he announced during Teva’s quarterly call, which will continue over the next several months and produce results sometime in the middle of 2023. That means some pipeline cuts may be in store, he told Endpoints News, while declining to offer much more detail.

FDA Commissioner Robert Califf on Capitol Hill, Feb. 8, 2023 (Drew Angerer/Getty Images)

FDA com­mis­sion­er floats ideas on how to bet­ter han­dle the pan­dem­ic

FDA Commissioner Rob Califf joined the heads of the CDC and NIH in the hot seat today before a key House subcommittee, explaining that there needs to be a much faster, more coordinated way to oversee vaccine safety, and that foreign biopharma inspections, halted for years due to the pandemic, are slowly ramping up again.

Califf, who stressed to the House Energy and Commerce’s Subcommittee on Health that the CDC also needs better data, made clear that the FDA’s ability to monitor the safety of vaccines “would also benefit greatly by a coordinated federal public health data reporting authority.”

Sanofi is renewing its #VaccinesForDreams campaign with more stories, such as Juan's in Argentina (Sanofi)

Sanofi re­news so­cial cam­paign to re­mind that vac­cines let peo­ple ‘Dream Big’

Sanofi is highlighting people’s dreams — both big and small — to make the point that vaccines make them possible.

The renewed “Dream Big” global social media campaign’s newest dreamer is Juan, a teacher in the Misiones rainforest in Argentina whose story is told through videos on Instagram and Sanofi’s website with the hashtag #VaccinesForDreams.

The campaign ties to Sanofi’s broader umbrella initiative “Vaccine Stories” to promote the value of vaccines and drive awareness of the need for improved vaccination coverage.

Endpoints News

Keep reading Endpoints with a free subscription

Unlock this story instantly and join 159,000+ biopharma pros reading Endpoints daily — and it's free.