Flag­ship-backed Foghorn woos Bris­tol-My­ers vet Carl De­ci­c­co to di­rect its 'gene traf­fic con­trol' plat­form

A num­ber of years ago, Carl De­ci­c­co hap­pened to catch a pre­sen­ta­tion by a young Dana-Far­ber re­searcher named Cigall Kadoch. She was talk­ing about the BAF chro­matin re­mod­el­ing com­plex and the im­por­tance of it in med­i­cine.

“I re­mem­ber think­ing that if she’d ever be able to ac­com­plish what she was propos­ing, it would be quite an area to be a part of,” he says.

Cigall Kadoch

That be­came re­al­i­ty this week as De­ci­c­co leaves a decades-long ca­reer at Bris­tol-My­ers Squibb to be­come chief sci­en­tif­ic of­fi­cer #1 and em­ploy­ee #51 at Foghorn Ther­a­peu­tics, a biotech co-found­ed by Kadoch to fo­cus on the chro­matin reg­u­la­to­ry sys­tem.

It’s been an in­ter­est­ing change, De­ci­c­co tells me, from a po­si­tion man­ag­ing a dis­cov­ery team of 2,000 spread among nine sites to a “much tighter” col­le­gial en­vi­ron­ment. But while work­ing for a biotech might mean a high­er lev­el of fo­cus, cer­tain things about bona fide drug dis­cov­ery pro­grams will re­main the same.

“I feel like my ca­reer is all about dri­ving these over the fin­ish line,” he says. “There is a for­mu­la ac­tu­al­ly for suc­cess­ful pro­grams and it does res­onate no mat­ter where you are, whether you’re in Big Phar­ma or a small com­pa­ny.”

Adri­an Gottschalk

De­ci­c­co’s new home in the boom­ing biotech hub of Cam­bridge — with­in walk­ing dis­tance from the of­fice — al­so al­lows him to par­tic­i­pate more broad­ly with the rest of the play­ers op­er­at­ing in the area. As the newest ven­ture part­ner at Flag­ship Pi­o­neer­ing he will get a front row seat in the cre­ation of new com­pa­nies, pro­vid­ing in­put on the port­fo­lio and po­ten­tial­ly sit­ting on some boards.

Doug Cole

Doug Cole, man­ag­ing part­ner at Flag­ship and a co-founder of Foghorn, de­scribes De­ci­c­co as a “drug dis­cov­ery lu­mi­nary” with “un­sur­passed tal­ents as a ‘drug hunter,’” hav­ing played a role in the ad­vance­ment of more than 200 com­pounds and 20 ap­proved drugs.

His top pri­or­i­ty, De­ci­c­co says, is scal­ing Foghorn’s gene traf­fic con­trol plat­form and pick­ing the pro­grams to set up project teams around so that they will be ready for clin­i­cal tri­als by 2020 — a goal set by CEO Adri­an Gottschalk.

And mov­ing past the near-term fo­cus on can­cer, the com­pa­ny has al­ready high­light­ed how reg­u­lat­ing chro­matin — the bind­ing ma­te­r­i­al that’s used to pack­age DNA in­to cells — could lead to new ther­a­peu­tic tar­gets in neu­ro­science and im­munol­o­gy.

It will all play out in the next three to five years as De­ci­c­co fig­ures out the right mix of peo­ple, skills and pro­grams for the re­search or­ga­ni­za­tion he’s run­ning. “I’m ex­cit­ed about be­ing close to the sci­ence,” he says.

How Pa­tients with Epilep­sy Ben­e­fit from Re­al-World Da­ta

Amanda Shields, Principal Data Scientist, Scientific Data Steward

Keith Wenzel, Senior Business Operations Director

Andy Wilson, Scientific Lead

Real-world data (RWD) has the potential to transform the drug development industry’s efforts to predict and treat seizures for patients with epilepsy. Anticipating or controlling an impending seizure can significantly increase quality of life for patients with epilepsy. However, because RWD is secondary data originally collected for other purposes, the challenge is selecting, harmonizing, and analyzing the data from multiple sources in a way that helps support patients.

$DNA is once again on NYSE; FDA clears Soliris chal­lenger for the mar­ket; Flag­ship’s think­ing big again with eR­NA; and more

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Re­gen­eron's Evkeeza shows promise in curb­ing high triglyc­erides, but will ge­net­ic dis­par­i­ties lim­it use?

When Regeneron scored an early approval for lipid lowering antibody Evkeeza back in February, the drugmaker cracked open a new pathway to lower abnormally high cholesterol levels. Now, Regeneron is chasing high triglycerides as well with some promising mid-stage data — but will genetic restrictions limit the drug’s use?

Regeneron’s Evkeeza (evinacumab) cut median triglyceride levels by more than 800 mg/dL (57%) in patients with a rare disorder causing abnormally high triglyceride levels compared with an overall increase of 50 mg/dL (1.8%) in participants on placebo, according to Phase II data presented Sunday at the virtual American College of Cardiology meeting.

Michael Dell (Richard Drew, AP Images)

'Dude, you're get­ting a Del­l' — as a new deep-pock­et biotech in­vestor

What happens when you marry longtime insiders in the global biotech VC game with the family fund of tech billionaire Michael Dell, a synthetic biology legend out of MIT and Harvard and the former director of the NCI?

Today, the answer is a newly financed, $200 million biotech SPAC now cruising the industry for a top player interested in finding a short cut to Nasdaq.

Orion Biotech Opportunities priced their blank check company today, raising $200 million with Dell’s multibillion-dollar MSD group’s commitment on investing another $20 million in a forward-purchase agreement.

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As­traZeneca's Farx­i­ga missed big on Covid-19 study, but it's tak­ing SGLT2 safe­ty da­ta as a sil­ver lin­ing

AstraZeneca hasn’t seen many setbacks in recent months for SGLT2 inhibitor Farxiga, which broke ground in heart failure and kidney disease regardless of diabetes diagnosis. But the British drugmaker had to admit defeat in taking Farxiga into Covid-19, but follow-up results add a bit of a silver lining to that trial’s safety data.

Of hospitalized Covid-19 patients dosed with AstraZeneca’s Farxiga, 11.2% experienced an organ failure or died after 30 days of therapy compared with 13.8% of those given placebo, according to follow-up data from the DARE-19 study revealed Sunday at the virtual American College of Cardiology meeting.

Pfiz­er, Bris­tol My­er­s' Eliquis flops in post-heart surgery pa­tients, spurring an 'un­ex­plained sig­nal' in cer­tain deaths

Pfizer and Bristol Myers Squibb’s non-warfarin blood thinner Eliquis has raced out to become the most prescribed drug of its class on the market — even overtaking warfarin’s long-time lead. But in tricky-to-treat patients after a valve replacement, an investigator-sponsored study couldn’t turn up benefit and raised a troubling safety signal.

Eliquis failed to show benefit over standard of care in preventing serious clinical outcomes after a transaortic valve replacement (TAVR) and was linked to an “unexplained signal” in a subset of populations with a higher rate of non-CV deaths who did not need blood thinners apart from the surgery, according to data presented Saturday at the virtual American College of Cardiology meeting.

Vas Narasimhan (Photographer: Simon Dawson/Bloomberg via Getty Images)

No­var­tis whiffs on En­tresto study af­ter heart at­tacks — but that does­n't mean it's go­ing down qui­et­ly

If Novartis learned one thing from its interaction with the FDA over its latest heart failure approval for Entresto, it was that missing a primary endpoint may not be the nail in the coffin. Now, Entresto has missed again on a late-stage study in high-risk heart patients, and it’s already sowing the seeds for a path forward regardless.

Novartis’ Entresto couldn’t best standard-of-care ramipril in staving off a composite of deaths and heart failure events in patients with left ventricular systolic dysfunction and/or pulmonary congestion who have had a prior heart attack, according to topline data from the Phase III PARADISE-MI study revealed Saturday at the virtual American College of Cardiology meeting.

Gene ther­a­py from Bio­gen's $800M buy­out flops in mid-stage study, deal­ing blow to new am­bi­tions

The #2 candidate from Biogen’s $800 million ocular gene therapy buyout has failed in a mid-stage trial, dealing an early blow to the big biotech’s plans to revitalize its pipeline with new technologies.

Biogen announced that the candidate, an experimental treatment for a rare and progressive form of blindness called X-linked retinitis pigmentosa (XLRP), failed to sufficiently improve vision in patients’ treated eye — patients only received an injection in one eye — after a year, on a standard scale, compared to their untreated eye. The company said they saw “positive trends” on several secondary endpoints, including visual acuity, but declined to say whether the trial actually hit any of those endpoints.

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Bris­tol My­ers backs up its case for heart drug mava­camten as FDA weighs app in car­diomy­opa­thy

When Bristol Myers Squibb signed off on its $13 billion acquisition of MyoKardia back in October, it was making a big bet that lead drug mavacamten could prove a game changer in cardiac myopathy. Now, with the drug up for FDA review, Bristol Myers is backing up its case with new quality of life data.

Patients dosed with myosin inhibitor mavacamten posted a clinically significant increase in scores on the Kansas City Cardiomyopathy Questionnaire, a catch-all summary of symptoms and quality of life markers, over placebo at 30 weeks, according to data from the Phase III EXPLORER-HCM study presented Saturday at the virtual American College of Cardiology meeting.