French biotech lands man­u­fac­tur­ing deal in step to­ward com­mer­cial­iza­tion of rare bone dis­ease drug

As a start­up, it can some­times be tough to think too far ahead in the fu­ture. How­ev­er, with a ma­jor man­u­fac­tur­ing part­ner­ship an­nounced Wednes­day, CTO Ca­r­ole Schwint­ner and her team at MaaT Phar­ma are tak­ing the first steps to­ward es­tab­lish­ing a long-term game plan for the sev­en-year-old com­pa­ny.

The French biotech and CD­MO Skyephar­ma will part­ner to build the largest spe­cial­ized man­u­fac­tur­ing fa­cil­i­ty for mi­cro­bio­me-based ther­a­peu­tics. The plant will help MaaT in­crease its out­put by ten-fold by 2030, with the aim to pro­duce sev­er­al thou­sand en­e­mas of the lead can­di­date MaaT-013, to treat Graft-ver­sus-Host dis­ease (GvHD), which hap­pens when do­nat­ed bone mar­row or stem cells view the re­cip­i­ent’s body as for­eign, and do­nat­ed cells and bone mar­row at­tack the body. It will al­so pro­duce “sev­er­al hun­dreds of thou­sands cap­sules” of MaaT-033, for pa­tients who re­ceive an al­lo­gene­ic stem cell trans­plan­ta­tion.

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