Gene therapy pioneer James Wilson sounds an alarm on high-dose AAV studies following toxic reactions in monkeys
Penn professor James Wilson is one of the preeminent scientists working today in gene therapy. He’s also the key figure in a fatal gene therapy trial back in the late ’90s that left the field in limbo for years, until a new generation of biotechs hustled ahead with the current wave of vector-carried corrective genes in the clinic — with an historic first approval in the US for Spark.
So when it surfaced that Wilson had quit an advisory role at Solid Bio $SLDB over safety issues associated with high-dose AAV gene therapy treatments — which coincided with a partial FDA hold on Solid’s high-dose work that was announced just hours before it priced its $125 million IPO — that sounded an alarm to some people in the field.
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