Genentech beefs up its PD-L1 combo pipeline, signing the 'don’t eat me' specialists at Forty Seven
After expanding its partnership with Syndax $SNDX earlier this week on their lead drug, Genentech has beefed up their pipeline of PD-L1 combos with a fresh pact with Stanford spinout Forty Seven.
The biotech put out word that Genentech will combine their two checkpoint drugs for use against acute myeloid leukemia and bladder cancer, with the big Roche subsidiary sponsoring the studies.
Tecentriq was the fourth PD-1/L1 checkpoint to hit the market, taking one foot off the brake of an immune response targeting cancer cells. Forty Seven, the brainchild of Stanford’s legendary investigator Irv Weissman, targets the “don’t eat me” signal cancer cells employ to hide out from a macrophage assault. The drug works by binding Hu5F9-G4 to CD47.
Unlock this article instantly by becoming a free subscriber.
You’ll get access to free articles each month, plus you can customize what newsletters get delivered to your inbox each week, including breaking news.